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Table 1 Summary of study characteristics of studies included in this literature review

From: Hypopituitarism after subarachnoid haemorrhage, do we know enough?

  Study design Inclusion criteria Exclusion criteria Selection bias Lost to FU nr Dynamic tests Analysis Results
Aimaretti et al. [37] Prospective cohort - - yes 0 GHRH-arg + +
Brandt et al. [33] Case series + + yes 0 TRH test & ITT (7 out of 10 pts) + +
Dimopoulou et al. [17] Retrospective cohort + + yes 0 none + +
Kreitschmann-Andermahr et al. [35] Retrospective cohort + + yes 10 TRH-LHRH test & ITT + +
Aimaretti et al. [32] Prospective cohort - - yes 0 GHRH-arg + +
Kreitschmann- Andermahr et al. [36] Case series + + yes 8 ITT (14 out of 45 pts) + +
Jovanovic et al. [34] Case series + + yes 0 none + +
Tanriverdi et al. [39] Prosective cohort + + no 0 GHRH-arg & glucagon test + +
Klose et al. [40] Prospective cohort + + no 0 ITT (GHRH-arg if contraindicated) + +
Lammert et al. [38] Prospective cohort + + yes 4 ACTH stimulation test (ITT in some patients) + +
Dutta et al. [46] Retrospective cohort + + yes 0 none + +
Gardner et al. [41] Prospective cohort + + no 0 GHRH-arg and glucagon test + +
Khursheed et al. [43] Prospective cohort + + no 0 none + +
Kronvall et al. [44] Prospective cohort + + no 6 GHRH-arg no no
Karaca et al. [45] Prospective cohort + + no 2 Glucagon test + +
Blijdorp et al. [42] Prospective cohort + + yes 0 Ghrelin test and GHRH-arg, Synacten test in some patients + +
  1. +: inclusion criteria, exclusion criteria, assessment methods and results clearly defined and reflected, -: inclusion criteria, exclusion criteria, assessment methods and results not or not clearly defined.
  2. GHRH- arg test: growth hormone releasing hormone plus arginine test, ITT: insulin tolerance test, d: TRH: thyrotropin releasing hormone, ACTH: adrenocorticotropic hormone, LHRH: gonadotropin releasing hormone, lost to FU number: number of patients lost in follow up of studies with more than one measurement overtime.