Web-based tool for dynamic functional outcome after acute ischemic stroke and comparison with existing models

Ji, Ruijun; Du, Wanliang; Shen, Haipeng; Pan, Yuesong; Wang, Penglian; Liu, Gaifen; Wang, Yilong; Li, Hao; Zhao, Xingquan; Wang, Yongjun

doi:10.1186/s12883-014-0214-z

BMC Neurology

Table 2 Multivariable analysis

From: Web-based tool for dynamic functional outcome after acute ischemic stroke and comparison with existing models

Predictors	Discharge mRS ≤ 2*			3-month mRS ≤ 2*			6-month mRS ≤ 2*			1-year mRS ≤ 2*
Predictors	ß-coefficient	OR (95% C.I.)	P	ß-coefficient	OR (95% C.I.)	P	ß-coefficient	OR (95% C.I.)	P	ß-coefficient	OR (95% C.I.)	P
Intercept	2.855			4.010			4.355			3.892
Age (per 1 year increase)	−0.02	0.98 (0.97-0.98)	<0.0001	−0.043	0.96 (0.95-0.96)	<0.0001	−0.050	0.95 (0.95-0.96)	<0.0001	−0.058	0.94 (0.94-0.95)	<0.0001
Gender (male)	0.295	1.34 (1.19-1.52)	<0.0001	0.234	1.26 (1.14-1.40)	<0.0001	0.189	1.21 (1.09-1.34)	<0.0001	0.274	1.32 (1.18-1.47)	<0.0001
Risk factors
Diabetes mellitus (No)	0.204	1.23 (1.08-1.39)	0.001	0.289	1.34 (1.17-1.52)	<0.0001	0.296	1.34 (1.18-1.53)	<0.0001	0.239	1.27 (1.11-1.45)	<0.0001
Stroke/TIA (No)	…	…	…	0.278	1.32 (1.18-1.49)	<0.0001	0.316	1.37 (1.22-1.55)	<0.0001	0.371	1.45 (1.30-1.62)	<0.0001
Current smoking (No)	0.157	1.17 (1.03-1.33)	0.01	…	…	…	…	…	…	…	…	…
Atrial fibrillation (No)	…	…	…	0.218	1.24 (1.02-1.52)	0.03	0.230	1.26 (1.03-1.53)	0.03	0.303	1.35 (1.11-1.65)	0.003
Pre-stroke independence (mRS ≤ 2)	0.549	1.73 (1.47-2.04)	<0.0001	0.588	1.80 (1.51-2.15)	<0.0001	0.672	1.96 (1.65-2.33)	<0.0001	0.634	1.89 (1.58-2.22)	<0.0001
pre-stroke statins using (Yes)	…	…	…	0.198	1.22 (1.10-1.35)	<0.0001	0.213	1.24 (1.12-1.37)	<0.0001	0.263	1.30 (1.17-1.44)	<0.0001
Admission NIHSS score (per 1 increase)	−0.197	0.82 (0.81-0.83)	<0.0001	−0.211	0.81(0.80-0.82)	<0.0001	−0.196	0.82 (0.81-0.83)	<0.0001	−0.185	0.83 (0.82-0.84)	<0.0001
Admission BG (per 1 mmol/L increase)	−0.044	0.96 (0.94-0.98)	<0.0001	−0.043	0.95 (0.93-0.97)	<0.0001	−0.054	0.95 (0.93-0.97)	<0.0001	−0.061	0.94 (0.92-0.96)	<0.0001

Multivariable logistic regression adjusted for age, gender, stroke risk factors, pre-existing comorbidities, pre-stroke dependence, pre-admission medications (anticoagulant with warfarin, anti-platelet medication, and statins), transport model to hospital, time from onset to hospital arrival, admission systolic and diastolic blood pressure, NIHSS score, OCSP subtypes, and admission blood glucose.
*Probability of good functional outcome (mRS ≤ 2) is calculated by P = e^Y/(1 + e^Y), where Y = a + b₁X₁ + b₂X₂ +.•. .. + b_iX_i;
Abbreviation: OR Odds Ratio, C.I. Confidence Interval, VIF Variance Inflation Factor, TIA Transient Ischemic Attack, mRS Modified Rankin Scale, NIHSS National Institutes of Health Stroke Scale score, BG Blood glucose.

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