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Table 1 Comparison of the different variables between NAb- and NAb + patients

From: Neutralizing antibodies and fatigue as predictors of low response to interferon-beta treatment in patients with multiple sclerosis

 

NAb- (n = 136)

NAb + (n = 39)

p

Female sex

95 (69.9%)

35 (89.7%)

0.012

Mean age at MS diagnosis (years +/- SEM)

33.8 +/- 0.9

35.2 +/- 1.5

0.48

Mean age at treatment initiation (years +/- SEM)

35.5 +/- 0.9

37.3 +/- 1.6

0.32

Mean duration of MS course (years +/- SEM)

5.3 +/- 0.5

4.9 +/- 0.9

0.66

Mean EDSS at inclusion consultation (+/- SEM)

1.7 +/- 0.1

1.8 +/- 0.2

0.66

Mean ΔEDSS* (+/- SEM)

+0.1 +/- 0.1

+0.4 +/- 0.1

0.035

Mean number of relapse before inclusion consultation (+/- SEM)

2.4 +/- 0.1

2.4 +/- 0.2

0.98

Mean number of relapse between inclusion and follow-up consultations (+/- SEM)

0.6 +/- 0.1

1.0 +/- 0.2

0.016

Number of non-responder patients

69 (50.7%)

27 (69.2%)

0.041

Mean MFIS score (+/- SEM)

34.2 +/- 1.7

47.3 +/- 2.9

0.0002

Number of fatigue patients

69 (50.7%)

31 (79.5%)

0.0014

Mean MADRS score (+/- SEM)

3.6 +/- 0.4

4.8 +/- 0.7

0.14

Mean MSTCQ score (+/- SEM)

7.2 +/- 0.4

5.9 +/- 0.8

0.086

IFNβ type:

   

- Intramuscular IFNβ-1a

25 (18.5%)

3 (7.9%)

0.21

- Subcutaneous IFNβ-1a

77 (57%)

22 (57.9%)

 

- Subcutaneous IFNβ-1b

33 (24.4%)

13 (34.2%)

 
  1. *ΔEDSS = EDSS at the follow-up consultation – EDSS at the inclusion consultation.