From: High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia
Men/Women | 27/20 |
---|---|
Mean age (range), years | 44 ± 19 (6 – 74) |
Mean age at onset (range), years* | 28 ± 19 (1 – 69) |
Mean disease duration (range), years* | 17 ± 12 (3 – 43) |
Clinical features | |
Asymptomatic individuals | 3/47 (6%) |
Increased tendon reflexes in the upper limbs | 40/47 (85%) |
Increased tendon reflexes in the lower limbs | 47/47 (100%) |
Presence of extensor plantar reflex | 29/45 (64%) |
Presence of ankle clonus | 23/42 (55%) |
Attenuated vibration perception at the ankles | 23/45 (51%) |
Dysfunction of bladder control† | 21/46 (46%) |
Ambulation function, 0/1/2/3/4 | 3/12/14/16/2 |
case No. (%)‡ | (6%/26%/30%/34%/4%) |