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Table 2 Clinical characteristics of the SPG4 patients (n = 47)

From: High frequency of SPG4 in Taiwanese families with autosomal dominant hereditary spastic paraplegia

Men/Women

27/20

Mean age (range), years

44 ± 19 (6 – 74)

Mean age at onset (range), years*

28 ± 19 (1 – 69)

Mean disease duration (range), years*

17 ± 12 (3 – 43)

Clinical features

 

Asymptomatic individuals

3/47 (6%)

Increased tendon reflexes in the upper limbs

40/47 (85%)

Increased tendon reflexes in the lower limbs

47/47 (100%)

Presence of extensor plantar reflex

29/45 (64%)

Presence of ankle clonus

23/42 (55%)

Attenuated vibration perception at the ankles

23/45 (51%)

Dysfunction of bladder control

21/46 (46%)

Ambulation function, 0/1/2/3/4

3/12/14/16/2

case No. (%)

(6%/26%/30%/34%/4%)

  1. *asymptomatic cases not included.
  2. urinary retention, frequency or incontinence.
  3. 0, asymptomatic; 1, able to run; 2, unable to run, walking independently; 3, walking with an aid; 4, wheelchair bound.