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Table 2 Clinical characterisation and MRI follow-up of NMOSD patients with SCA (n = 23)

From: Comparison of clinical characteristics between neuromyelitis optica spectrum disorders with and without spinal cord atrophy

Clinical manifestations

NMO-IgG positive (n = 16)

NMO-IgG negative (n = 7)

F/M

13/3

6/1

Duration of disease

0-4 y

6

2

5-9 y

5

2

10- y

5

3

Brain lesion(n)

  

 Brain lobes

8

7

 Basal ganglia

3

2

 Hypothalamic and thalamic

4

2

 Mesencephalon

1

1

 Pons

5

3

 Medulla oblongata

4

2

 Peri-ventricle and peri-aqueduct

4

3

 Cerebellum

3

0

Spinal cord lesions(n)

  

LETM

21

5

STM

8

4

Focal atrophy of SC

14

5

General atrophy of SC

6

3

Atrophy of STM

13

3

Atrophy of LETM

9

4

  1. NMOSD = neuromyelitis optica spectrum disorders; SCA = spinal cord atrophy; NMO-IgG = anti-AQP4IgG autoantibodies; LETM = longitudinally extensive transverse myelitis; STM = shorter transverse myelitis; SC = Spinal cord.