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Table 4 Comparative brain and spinal cord lesions on MRI of patients with or without SCA in NMOSD

From: Comparison of clinical characteristics between neuromyelitis optica spectrum disorders with and without spinal cord atrophy

 

NMOSD with SCA (n = 23)

NMOSD without SCA (n = 162)

P

Brain lesions, n (%)

 Brain lobes

15 (65.2%)

71 (46.5%)

0.054

 Basal ganglia

5 (21.7%)

26 (16%)

0.494

 Hypothalamic and thalamic

6 (26.1%)

19 (11.7%)

0.059

 Medulla oblongata

8 (34.8%)

31 (19.1%)

0.085

 Pons

8 (34.8%)

32 (19.8%)

0.101

 Mesencephalon

2 (8.7%)

6 (4.3%)

0.271

 Peri-ventricleand peri-aqueduct

7 (30.4%)

35 (21.6%)

0.344

 Cerebellum

3 (13%)

8 (4.9%)

0.124

Spinal cord lesions, n (%)

   

Cervical cord

20 (87%)

79 (48.4%)

0.001**

Segments lesions

4.74 ± 1.91

4.65 ± 1.87

0.849

LETM

13 (56.5%)

62 (59%)

0.842

STM

10(43.5%)

32 (30.5%)

0.229

Thoracic cord

3 (13%)

62 (38.3%)

0.018*

Segments lesions

6.00 ± 3.37

5.53 ± 2.93

0.549

LETM

18 (73.9%)

67 (65.7%)

0.448

STM

6 (26.1%)

26 (24.8%)

0.894

Cervical and thoracic cord

17 (73.9%)

45 (27.8%)

0.001**

  1. MRI = magnetic resonance imaging; SCA = spinal cord atrophy; NMOSD = neuromyelitis optica spectrum disorders; LETM = longitudinally extensive transverse myelitis; STM = shorter transverse myelitis; *P < 0.05; **P < 0.01.