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Figure 2 | BMC Neurology

Figure 2

From: Trigeminal isolated sensory neuropathy (TISN) and FOSMN syndrome: despite a dissimilar disease course do they share common pathophysiological mechanisms?

Figure 2

Electron microscopy. Upper panel: low-power electron micrographs taken on ultrathin sections from the supraorbital nerve in Patients 2 (A), 3 (B) and 11 (C). Bar: 10 μm. The supraorbital nerve contains remarkably fewer large myelinated than small myelinated fibres. The macrophage in C (arrow) indicates axonal breakdown and phagocytosis. Lower panel: high-power electron micrographs taken on ultrathin sections from the supraorbital nerve in Patient 6 (D,E) and Patient 9 (F). Bar: 10 μm in D, 5 μm in E, and 1 μm in F. Myelin debris in Schwann cells (arrows), indicating myelin degradation in D and E. The asterisks in F and D indicate intact unmyelinated fibres.

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