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Table 1 Demographic and clinical data of ALS patients and differentials

From: The diagnostic value of midbrain hyperechogenicity in ALS is limited for discriminating key ALS differential diagnoses

 

ALS

MG

IN

CCS

P value

No. of patients, n

43

29

25

13

 

Female, n (%)

21 (49%)

12 (41%)

9 (36%)

6 (46%)

0.779*

Age (yr), Mean ± SD (range)

64.9 ± 9.6 (42–78)

61.7 ± 14.5 (34–83)

60.6 ± 16.1 (22–80)

62.5 ± 10.7 (48–81)

0.554#

ALS subtype

     

 Bulbar, n (%)

11/43 (17%)

-

-

-

-

 Spinal, n (%)

28/43 (65%)

-

-

-

-

ALS-FRSR, mean ± SD (range)

33.6 ± 9.45 (14–48)

-

-

-

-

MG subtype

     

 Ocular, n (%)

-

6/28 (21%)

-

-

-

 Bulbar, n (%)

-

4/28 (14%)

-

-

-

 Generalized, n (%)

-

17/28 (61%)

-

-

-

IN subtypes

     

 CIDP

-

-

13/25 (52%)

-

-

 GBS

-

-

4/25 (16%)

-

-

 MMN

-

-

4/25 (16%)

-

-

 MADSAM

-

-

2/25 (8%)

-

-

 AMSAN

-

-

1/25 (4%)

-

-

 Mononeuritis muliplex

-

-

1/25 (4%)

-

-

CCS

     

 Degree; absolute/high

-

-

-

7/3

-

 Myelopathy, n (%)

-

-

-

10/12 (83%)

-

 Paraspasticity, n(%)

-

-

-

3/11 (27%)

-

  1. *Fisher exact test; #One-way two-sided ANOVA. Denominators may differ due to missing data in some individuals.
  2. ALS, amyotrophic lateral sclerosis; MG, Myasthenia gravis; IN, inflammatory neuropathies; CIDP, chronic inflammatory demyelinating polyneuropathy; GBS, Guillain-Barré-Syndrome; MMN, multifocal motor neuropathy; MADSAM, multifocal acquired demyelinating sensory and motor neuropathy; AMSAM, acute motor and sensory axonal neuropathy; CCS, cervical canal stenosis.