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Table 1 Schedule of assessments

From: Cohort study ON Neuroimaging, Etiology and Cognitive consequences of Transient neurological attacks (CONNECT): study rationale and protocol

Assessment

Baseline

Follow-up

Demographics

  

Age, sex

X

 

Education

X

 

Working status

X

 

Marital status

X

 

Structured assessment of TIA/TNA presentation

  

Duration of symptoms

X

 

Number of episodes in week before inclusion

X

 

Focal symptoms*

X

 

Nonfocal symptoms*

X

 

Incident focal symptoms*

 

X

Incident nonfocal symptoms*

 

X

Medical history

  

Hypertension

X

X

Dyslipidemia

X

X

Diabetes mellitus

X

X

Atrial fibrillation

X

X

Other cardiovascular diseases

X

 

First-degree relatives with cardiovascular disease

X

 

Smoking status

X

X

Alcohol consumption

X

X

Drug abuse

X

X

Hypercoagulability

X

 

Acute infection

X

 

Migraine

X

 

Previous TIA/TNA

X

 

Carotid endarterectomy

X

X

Epilepsy

X

X

Depression

X

X

Current medication use

X

X

Incident cardiovascular events

 

X

Incident TIA, cerebral infarction or hemorrhage

 

X

Physical examination

  

Length and weight, BMI

X

 

Blood pressure

X

 

Neurological examination

X

 

ECG

  

(Paroxysmal) atrial fibrillation

X

 

Ischemia

X

 

Left ventricular hypertrophy

X

 

Fasting laboratory investigations

  

Glucose

X

 

Lipid profile

X

 

Creatinine

X

 

Neuropsychological assessment

  

Global cognitive function

  

Mini Mental State Examination

X

 

Frontal Assessment Battery

X

X

Episodic memory

  

Rey Auditory Verbal Learning Test

X

X

Executive function

  

Verbal fluency

X

X

Stroop Color Word Test (interference score)

X

X

Brixton Spatial Anticipation Test

X

X

Information processing speed

  

Symbol-Digit Modalities Test

X

X

Stroop Color Word Test (Cards I and II)

X

X

Attention

  

Verbal Series Attention Test

X

X

Subjective cognitive failures

  

Cognitive failures Questionnaire

X

X

Depressive symptoms

  

Hospital Anxiety and Depression Scale

X

X

Sleep disorders

  

Scales for Outcomes in Parkinson’s Disease - Sleep

X

X

Fatigue

  

Checklist on Individual Strength

X

X

Prior cognitive performance

  

Informant Questionnaire on Cognitive Decline in the Elderly

X

X

MRI

  

Anatomical sequences (T1, T2, FLAIR, T2*)

X

X

Diffusion-weighted imaging

X

 

MR angiography

X

 

Susceptibility-weighted imaging

 

X

Diffusion tensor imaging

 

X

Resting-state functional MRI

 

X

  1. Empty cells indicate no assessment. BMI indicates body-mass index; FLAIR, fluid-attenuated inversion recovery; TNA, transient neurological attack; ToF, time-of-flight.
  2. *Presence of 18 predefined symptoms, both focal and nonfocal (see also Table 2).
  3. Myocardial infarction, coronary artery bypass grafting, percutaneous transluminal coronary angioplasty, valvular heart disease and peripheral revascularization procedures.