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APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study

  • Lucette A Cysique1, 2, 3, 4Email author,
  • Timothy Hewitt4, 5,
  • Juliana Croitoru-Lamoury1, 4,
  • Kevin Taddei6, 7,
  • Ralph N Martins6, 7, 8,
  • Constance SN Chew9,
  • Nicholas NWS Davies10,
  • Patricia Price9 and
  • Bruce J Brew1, 3, 4
BMC Neurology201515:51

Received: 14 March 2014

Accepted: 11 March 2015

Published: 1 April 2015

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
14 Mar 2014 Submitted Original manuscript
Author responded Author comments
Reviewed Reviewer Report
Reviewed Reviewer Report
Reviewed Reviewer Report
Reviewed Reviewer Report
Resubmission - Version 2
Submitted Manuscript version 2
11 Mar 2015 Editorially accepted
1 Apr 2015 Article published 10.1186/s12883-015-0298-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

University of New South Wales, St. Vincent’s Hospital Clinical School, Sydney, Australia
Neuroscience Research Australia, Sydney, Australia
Department of Neurology St. Vincent’s Hospital, Sydney, Australia
St. Vincent’s Centre for Applied Medical Research, Sydney, Australia
University of Notre Dame, Sydney, Australia
Centre of Excellence for Alzheimer’s disease Research & Care, School of Medical Sciences, Edith Cowan University, Mount Lawley, Australia
Sir James McCusker Alzheimer’s Disease Research Unit, Hollywood Private Hospital, Nedlands, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia
School of Biomedical Science, Curtin University of Technology, Bentley, Australia
Department of Neurology, Chelsea & Westminster Hospital, London, UK