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Table 2 Correlations between individual CSF biomarkers, AD risk markers, HIV/HAND risk markers, current overall neurocognitive impairment and past HAND

From: APOE ε4 moderates abnormal CSF-abeta-42 levels, while neurocognitive impairment is associated with abnormal CSF tau levels in HIV+ individuals – a cross-sectional observational study

Correlations between

r

p

APOE

Log10 CSF t-tau

−0.09

0.59

Age

0.16

0.31

Nadir CD4

−0.19

0.22

HIV duration

0.04

0.78

Past HAND

0.10

0.50

GDS (current)

0.29

0.05

APOE

Log10 CSF p-tau

−0.11

0.47

Age

0.08

0.61

Nadir CD4

−0.18

0.26

HIV duration

−0.05

0.73

Past HAND

0.15

0.33

GDS (current)

0.32

0.03

APOE

CSF Aβ1-42

−0.50

0.001

Age

0.16

0.31

Nadir CD4

−0.09

0.58

HIV duration

−0.11

0.51

Past HAND

−0.06

0.70

GDS (current)

0.18

0.26

Log10 CSF p-tau

Log10 CSF t-tau

0.96

<.0001

CSF Aβ1-42

Log10 CSF t-tau

0.48

0.002

CSF Aβ1-42

Log10CSF p-tau

0.53

0.0004

  1. APOE Genotypes were coded as follows: no ε4 = 1; heterozygotes ε4/ε2 or ε4/ε3 = 2; genotypes: homozygotes ε4/ε4 = 3. Note that the correlation for APOE is driven by the ε4/ε4 cases and one ε4/ε3 case.
  2. We used Pearson and point-biserial correlations as appropriate.
  3. The Global Deficit Score (GDS) is a summary score that is an average of all the deficit scores across the test battery, and it grades normal vs. impaired performance between 0-5. A higher GDS indicated greater current overall impairment.
  4. Past HAND: History of HAND yes was coded 1; no was coded 0.
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BMC Neurology

ISSN: 1471-2377

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