From: Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis
Study | Study design | Inclusion criteria | Number of patients (% men) | Age (years) | Intervention | Outcomes |
---|---|---|---|---|---|---|
Bertolasi [2013] [14] | RCT | 18-70 y, history of paralytic polio; clinical stability > 15 years; new symptoms fulfilling the EFNS guidelines criteria | I: 24 (50) P: 26 (50) | I: 54.9 ± 5.7 P: 58.3 ± 5.6 | I: 0.4 g/kg/d × 5 d P: saline at the same volume | QoL, gait, muscle strength, fatigue, pain at 2 and 4 mo |
Farbu [2007] [12] | RCT | Ambulatory patients fulfilling the diagnostic criteria for PPS | I: 10 (40) P: 10 (30) | I: 59.9 ± 6.2 P: 58.7 ± 6.8 | I: 2 g/kg infused for 2–4 d P: saline at the same volume | Pain, muscle strength, fatigue at 1, 3, and 6 mo; changes in serum and CSF cytokine levels at 1 mo |
Gonzalez [2006] [10] | RCT | 18-75 y, history of polio; increased weakness, fatigue, and pain fulfilling the diagnostic criteria for PPS | I: 73 (29) P: 69 (42) | I: 61.5 ± 9.2 P: 59.0 ± 10.0 | I: 30 g × 3 d, twice at 3-mo intervals P: glucose water at the same volume | QoL, balance, fatigue, gait, muscle strength, physical activity, sleep quality, and pain at 9 − 13wk |
Gonzalez [2012] [5] | Prospective | 18-75 y, history of polio; increased weakness, fatigue, and pain fulfilling the diagnostic criteria for PPS | I: 20 (30) P: 21 (43) | I: 61.7 (52–75)†P: 61.9 (46–75) | I: 30 g × 3 d, twice at 3-mo intervals P: glucose water at the same volume | Cytokine expression in PBMCs and CSF, QoL, gait, pain at 1 year |
Gonzalez [2004] [13] | Prospective | Patients fulfilling the diagnostic criteria for PPS | I: 16 (56) | I: 58.5 (43–70)†| I: 30 g × 3 d | Cytokine expression in PBMCs and CSF at 6–8 wk |
Kaponides [2006] [8] | Prospective | Patients fulfilling the diagnostic criteria for PPS | I: 14 (57) | I: 57 (43–67)†| I: 30 g × 3 d | QoL at 2 and 6 mo; physical performance and muscle strength at 2 mo |
Östlund [2012] [11] | Prospective | Patients fulfilling the diagnostic criteria for PPS | I: 113 (45) | I: 66 ± 10 | I: 90 g infused for 3 d | QoL, physical activity, and pain at 6 mo |
Werhagen [2011] [9] | Prospective | Patients with PPS | I: 45 (36) | I: 61 (36–88)†| I: 30 g × 3 d | Pain at 6 mo |