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Table 1 Characteristics of the selected trials

From: Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis

Study Study design Inclusion criteria Number of patients (% men) Age (years) Intervention Outcomes
Bertolasi [2013] [14] RCT 18-70 y, history of paralytic polio; clinical stability > 15 years; new symptoms fulfilling the EFNS guidelines criteria I: 24 (50) P: 26 (50) I: 54.9 ± 5.7 P: 58.3 ± 5.6 I: 0.4 g/kg/d × 5 d P: saline at the same volume QoL, gait, muscle strength, fatigue, pain at 2 and 4 mo
Farbu [2007] [12] RCT Ambulatory patients fulfilling the diagnostic criteria for PPS I: 10 (40) P: 10 (30) I: 59.9 ± 6.2 P: 58.7 ± 6.8 I: 2 g/kg infused for 2–4 d P: saline at the same volume Pain, muscle strength, fatigue at 1, 3, and 6 mo; changes in serum and CSF cytokine levels at 1 mo
Gonzalez [2006] [10] RCT 18-75 y, history of polio; increased weakness, fatigue, and pain fulfilling the diagnostic criteria for PPS I: 73 (29) P: 69 (42) I: 61.5 ± 9.2 P: 59.0 ± 10.0 I: 30 g × 3 d, twice at 3-mo intervals P: glucose water at the same volume QoL, balance, fatigue, gait, muscle strength, physical activity, sleep quality, and pain at 9 − 13wk
Gonzalez [2012] [5] Prospective 18-75 y, history of polio; increased weakness, fatigue, and pain fulfilling the diagnostic criteria for PPS I: 20 (30) P: 21 (43) I: 61.7 (52–75) P: 61.9 (46–75) I: 30 g × 3 d, twice at 3-mo intervals P: glucose water at the same volume Cytokine expression in PBMCs and CSF, QoL, gait, pain at 1 year
Gonzalez [2004] [13] Prospective Patients fulfilling the diagnostic criteria for PPS I: 16 (56) I: 58.5 (43–70) I: 30 g × 3 d Cytokine expression in PBMCs and CSF at 6–8 wk
Kaponides [2006] [8] Prospective Patients fulfilling the diagnostic criteria for PPS I: 14 (57) I: 57 (43–67) I: 30 g × 3 d QoL at 2 and 6 mo; physical performance and muscle strength at 2 mo
Östlund [2012] [11] Prospective Patients fulfilling the diagnostic criteria for PPS I: 113 (45) I: 66 ± 10 I: 90 g infused for 3 d QoL, physical activity, and pain at 6 mo
Werhagen [2011] [9] Prospective Patients with PPS I: 45 (36) I: 61 (36–88) I: 30 g × 3 d Pain at 6 mo
  1. CSF, cerebrospinal fluid; EFNS, European Federation of Neurological Societies; I: intravenous immunoglobulin group; IVIg, intravenous immunoglobulin; P, placebo group; PBMCs, peripheral blood mononuclear cells; Polio, poliomyelitis; PPS, post-polio syndrome; QoL, quality of life; Data presented as the mean ± standard deviation except mean (range).