Receiver operating characteristic curves for Discovery and Validation cohorts. Receiver operating characteristic (ROC) curves are shown for scoring with APOE only (in blue) and the 17-marker risk score (“Q”, in red). AUC values of each curve are provided. (A) Discovery cohort shows a significant improvement in sensitivity/specificity as compared to APOE only, P < 0.00001. (B) Risk scoring with the 17-marker risk score in the Validation cohort does not increase prediction beyond APOE genotype alone.