Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease

BMC Neurology

Table 4 Risk scoring results for the Discovery and Validation cohorts

	Score	AUC ± SE	P-val vs. A	N
Discovery	A	0.69 ± 0.04	N/A	192
Discovery	Q	0.88 ± 0.03	<0.00001	192
Validation	A	0.63 ± 0.03	N/A	256
Validation	Q	0.62 ± 0.04	0.7345	256

Evaluation metrics for the APOE-only risk score (“A”) and the 17-marker risk score (“Q”). The 17-marker risk score predicted AD significantly better than APOE alone in the Discovery (P < 0.00001) but not the Validation cohort. Area under the curve (AUC) of the Receiver Operating Characteristic curves for A and Q and p-values of their comparisons are provided.

ISSN: 1471-2377