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Table 4 Risk scoring results for the Discovery and Validation cohorts

From: Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease

  Score AUC ± SE P-val vs. A N
Discovery A 0.69 ± 0.04 N/A 192
Q 0.88 ± 0.03 <0.00001
Validation A 0.63 ± 0.03 N/A 256
Q 0.62 ± 0.04 0.7345
  1. Evaluation metrics for the APOE-only risk score (“A”) and the 17-marker risk score (“Q”). The 17-marker risk score predicted AD significantly better than APOE alone in the Discovery (P < 0.00001) but not the Validation cohort. Area under the curve (AUC) of the Receiver Operating Characteristic curves for A and Q and p-values of their comparisons are provided.