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Table 2 Defined daily dose (DDD) for concomitant AEDs

From: Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a historical-control phase III study

AED

Approximately 2/3 DDD

Adult DDD

Carbamazepine*

700 mg

1000 mg

Ethosuximide

800 mg

1250 mg

Felbamate

1600 mg

2400 mg

Gabapentin

1200 mg

1800 mg

Levetiracetam

1000 mg

1500 mg

Lamotrigine*

200 mg (200 mg with enzyme inducers; 100 mg with valproate)

300 mg (400 mg with enzyme inducers; 150 mg with valproate)

Lacosamide

300 mg

200–400 mg

Oxcarbazepine*

700 mg (1000 mg with enzyme inducers)

1000 mg (2000 mg with enzyme inducers)

Phenobarbital

70 mg

100 mg

Pregabalin

200 mg

300 mg

Phenytoin*

200 mg

300 mg

Primidone

800 mg

1250 mg

Tiagabine

20 mg (30 mg with enzyme inducers)

30 mg (60 mg with enzyme inducers)

Topiramate

200 mg (300 mg with enzyme inducers)

300 mg (600 mg with enzyme inducers)

Vigabatrin

1400 mg

2000 mg

Valproate

1000 mg

1500 mg

Zonisamide

140 mg (200 mg with enzyme inducers)

200 mg (400 mg with enzyme inducers)

  1. Note: The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults [32].
  2. *Sodium channel blockers; Adult DDD information from product label.
  3. DDD = defined daily dose; AED = antiepileptic drug.