|
Characteristics
|
N
|
Events
|
Median time to EDSS4 (year)
|
p value
|
|---|
|
Age at onset of MS
| | | | |
|
<20
|
59
|
10
| |
0.0001
|
|
20–28
|
110
|
28
|
19.1
| |
|
29–38
|
119
|
48
|
10.0
| |
|
39–49
|
87
|
32
|
12.2
| |
|
≥50
|
32
|
24
|
4.2
| |
|
Sex
| | | | |
|
Male
|
119
|
60
|
8.0
|
0.0001
|
|
Female
|
288
|
82
|
16.6
| |
|
Initial course of MS
| | | | |
|
Remitting-relapsing
|
349
|
92
|
16.6
|
0.0001
|
|
Primary progressive
|
58
|
50
|
3.8
| |
|
Incomplete recovery from first relapse
| | | | |
|
No
|
346
|
117
|
19.1
|
0.3
|
|
Yes
|
61
|
25
|
11.9
| |
|
CSF total protein level, mg/L
| | | | |
|
0–500
|
312
|
100
|
19.1
|
0.02
|
|
≥500
|
95
|
42
|
10.6
| |
|
CSF IgG index
| | | | |
|
<0.60
|
219
|
83
|
16.6
|
0.6
|
|
≥0.60
|
188
|
59
|
11.4
| |
|
CSF oligoclonal bands
| | | | |
|
Yes
|
354
|
119
|
16.6
|
0.7
|
|
No
|
53
|
23
|
12.2
| |
|
Leukocyte count
| | | | |
|
Normal
|
151
|
57
|
11.9
|
0.2
|
|
Increased (≥5 mm3)
|
256
|
85
|
16.6
| |
|
Barkhof’s criteria (initial MRI)
| | | | |
|
Positive
|
359
|
129
|
16.6
|
0.4
|
|
Negative
|
48
|
13
| | |
|
Treatment
| | | | |
|
Yes
|
303
|
228
|
16.6
|
0.0001
|
|
No
|
104
|
37
|
4.9
| |
- P value: Kaplan-Meier method and Log-Rank Test; EDSS: Expanded Disability Status Scale; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging.
