Skip to main content

Advertisement

Table 2 Association of patient characteristics and median time from MS onset to expanded disability status scale score 4

From: No prognostic value of routine cerebrospinal fluid biomarkers in a population-based cohort of 407 multiple sclerosis patients

Characteristics N Events Median time to EDSS4 (year) p value
Age at onset of MS     
<20 59 10   0.0001
20–28 110 28 19.1  
29–38 119 48 10.0  
39–49 87 32 12.2  
≥50 32 24 4.2  
Sex     
Male 119 60 8.0 0.0001
Female 288 82 16.6  
Initial course of MS     
Remitting-relapsing 349 92 16.6 0.0001
Primary progressive 58 50 3.8  
Incomplete recovery from first relapse     
No 346 117 19.1 0.3
Yes 61 25 11.9  
CSF total protein level, mg/L     
0–500 312 100 19.1 0.02
≥500 95 42 10.6  
CSF IgG index     
<0.60 219 83 16.6 0.6
≥0.60 188 59 11.4  
CSF oligoclonal bands     
Yes 354 119 16.6 0.7
No 53 23 12.2  
Leukocyte count     
Normal 151 57 11.9 0.2
Increased (≥5 mm3) 256 85 16.6  
Barkhof’s criteria (initial MRI)     
Positive 359 129 16.6 0.4
Negative 48 13   
Treatment     
Yes 303 228 16.6 0.0001
No 104 37 4.9  
  1. P value: Kaplan-Meier method and Log-Rank Test; EDSS: Expanded Disability Status Scale; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging.