No prognostic value of routine cerebrospinal fluid biomarkers in a population-based cohort of 407 multiple sclerosis patients

Table 2 Association of patient characteristics and median time from MS onset to expanded disability status scale score 4

Characteristics	N	Events	Median time to EDSS4 (year)	p value
Age at onset of MS
<20	59	10		0.0001
20–28	110	28	19.1
29–38	119	48	10.0
39–49	87	32	12.2
≥50	32	24	4.2
Sex
Male	119	60	8.0	0.0001
Female	288	82	16.6
Initial course of MS
Remitting-relapsing	349	92	16.6	0.0001
Primary progressive	58	50	3.8
Incomplete recovery from first relapse
No	346	117	19.1	0.3
Yes	61	25	11.9
CSF total protein level, mg/L
0–500	312	100	19.1	0.02
≥500	95	42	10.6
CSF IgG index
<0.60	219	83	16.6	0.6
≥0.60	188	59	11.4
CSF oligoclonal bands
Yes	354	119	16.6	0.7
No	53	23	12.2
Leukocyte count
Normal	151	57	11.9	0.2
Increased (≥5 mm³)	256	85	16.6
Barkhof’s criteria (initial MRI)
Positive	359	129	16.6	0.4
Negative	48	13
Treatment
Yes	303	228	16.6	0.0001
No	104	37	4.9

P value: Kaplan-Meier method and Log-Rank Test; EDSS: Expanded Disability Status Scale; CSF: cerebrospinal fluid; MRI: magnetic resonance imaging.