Table 3 The Risk of Recurrence of Ischemic Stroke and Hemorrphagic Stroke in association with Antidepressants
Ischemic Stroke | Hemorrhagic Stroke | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Number of Recurrent Stroke/Person-years | Rate per 1000 Person-Years | Crude HR | (95 % CI) | Adjusted HRa | (95 % CI) | Number of Recurrent Stroke/Person-years | Rate per 1000 Person-Years | Crude HR | (95 % CI) | Adjusted HRa | (95 % CI) | |
Non-use of Antidepressants | 3012/61194 | 49.2 | 1 | 1 | 681/68749 | 9.9 | 1 | 1 | ||||
Use of Antidepressants | 217/2521 | 86.1 | 1.58 | (1.38, 1.82) | 1.48 | (1.28, 1.70) | 35/3098 | 11.3 | 1.10 | (0.78, 1.54) | 1.22 | (0.86, 1.73) |
Type of Antidepressants | ||||||||||||
TCAs only | 83/930 | 945.2 | 1.64 | (1.32, 2.04) | 1.53 | (1.23, 1.90) | 12/1113 | 10.8 | 1.03 | (0.58, 1.83) | 1.08 | (0.61, 1.91) |
SSRIs only | 49/653 | 649.7 | 1.46 | (1.10, 1.93) | 1.34 | (1.01, 1.79) | 8/794 | 10.1 | 1.03 | (0.51, 2.06) | 1.23 | (0.61, 2.48) |
MAOIs only | 8/93 | 92.6 | 1.36 | (0.68, 2.72) | 1.24 | (0.62, 2.49) | 2/111 | 18.0 | 1.53 | (0.38, 6.11) | 2.15 | (0.54, 8.68) |
Others only | 11/92 | 761.1 | 1.59 | (1.24, 2.03) | 1.50 | (1.17, 1.92) | 10/963 | 10.4 | 1.01 | (0.54, 1.88) | 1.12 | (0.60, 2.10) |
Multiple types | 66/756 | 92.2 | 2.06 | (1.14, 3.73) | 1.95 | (1.08, 3.54) | 3/117 | 25.7 | 2.51 | (0.81, 7.80) | 2.78 | (0.89, 8.68) |
Dose Group+ | ||||||||||||
<0.5 DDDs | 116/1322 | 87.7 | 1.58 | (1.31, 1.90) | 1.49 | (1.23, 1.79) | 16/1638 | 9.8 | 0.93 | (0.57, 1.53) | 1.00 | (0.61, 1.64) |
0.5–1 DDDs | 46/502 | 91.7 | 1.73 | (1.29, 2.31) | 1.59 | (1.19, 2.13) | 6/617 | 9.7 | 0.97 | (0.44, 2.18) | 1.11 | (0.50, 2.49) |
> = 1 DDDs | 55/697 | 78.9 | 1.48 | (1.13, 1.93) | 1.37 | (1.05, 1.80) | 13/844 | 15.4 | 1.53 | (0.89, 2.66) | 1.81 | (1.04, 3.16) |