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Table 2 Frequencies of pathologies within aMCI (N = 34) and naMCI (N = 15) cases. All pathology groups are not mutually exclusive; there is considerable overlap with concomitant pathologies

From: Neuropathological comparisons of amnestic and nonamnestic mild cognitive impairment

 

aMCI

naMCI

p value

Clinicopathologic diagnoses

   

 PD

8 (24 %)a

7 (47 %)

0.18

 PSP

3 (9 %)a

3 (20 %)

0.35

 MND

0

1 (7 %)

0.31

 MSA

1 (3 %)

0

1.00

Other pathologies

   

Met neuropath criteria for AD

18 (53 %)

8 (53 %)

1.00

 Braak NFT stage

  

0.22

  I

2 (6 %)

0

 

  II

2 (6 %)

2 (13 %)

 

  III

3 (9 %)

5 (33 %)

 

  IV

23 (68 %)

8 (53 %)

 

  V

3 (9 %)

0

 

  VI

1 (3 %)

0

 

 CERAD NP score

  

0.90

  None

12 (35 %)

6 (40 %)

 

  Sparse

2 (6 %)

1 (7 %)

 

  Moderate

8 (24 %)

2 (13 %)

 

  Frequent

12 (35 %)

6 (40 %)

 

Incidental LBs

5 (15 %)

0

0.31

Unified LB staging scheme

  

0.18

 Stage 0. no LBs

21 (62 %)

8 (53 %)

 

 Stage 1. OBT only

2 (6 %)

0

 

 Stage IIa. Brainstem

3 (9 %)

1 (7 %)

 

 Stage IIb. Limbic

3 (9 %)

0

 

 Stage III. Limbic + Brainstem

3 (9 %)

3 (20 %)

 

 Stage IV. Neocortical

2 (6 %)

3 (20 %)

 
  1. aOne aMCI case had both PSP and PD; there were no other overlapping clinicopathological diagnoses