Table 3 Semi-quantitative analyses of neuritic plaques (NP) and neurofibrillary tangles (NFT), Lewy-type synucleinopathy (listed as average (mean)), and other pathologies (listed as frequencies) within aMCI (N = 34) and naMCI (N = 15)

Neuritic plaques

 Frontal lobe

1.5 (1.3)

1.8 (1.3)

−1.0 to 0.6

0.55

 Temporal lobe

1.5 (1.3)

1.5 (1.3)

−0.7 to 0.9

0.88

 Parietal lobe

1.6 (1.3)

1.7 (1.7)

−1.0 to 0.7

0.76

 Hippocampus region

0.7 (0.9)

0.7 (0.8)

−0.53 to 0.53

1.00

 Entorhinal region

1.3 (1.3)

1.3 (1.0)

−0.8 to 0.8

0.97

Total (all areas; score out of 15)

6.6 (5.7)

1.2 (5.2)

−4.3 to 2.9

0.11

Neurofibrillary tangles

 Braak NFT stage

IV (I-VI)

III (II-IV)

−0.22 to 0.95

0.22

 Frontal lobe

0.4 (0.6)

0.2 (0.3)

−0.06 to 0.60

0.11

 Temporal lobe

1 (0.8)

0.6 (0.7)

−0.04 to 0.91

0.07

 Parietal lobe

0.4 (0.6)

0.1 (0.2)

−0.02 to 0.60

0.07

 Hippocampus region

2.2 (0.9)

2.0 (0.9)

−0.30 to 0.80

0.36

 Entorhinal region

2.6 (0.8)

2.5 (0.8)

−0.38 to 0.60

0.66

Total (all areas; score out of 15)

6.6 (2.8)

5.2 (2.3)

−0.3 to3.1

0.11

Lewy type synucleinopathy

 Olfactory bulb

1.1 (1.6)

1.5 (1.8)

−1.5 to 0.7

0.44

 Cingulate cortex

0.6 (1.1)

1.2 (1.6)

−1.4 to 0.1

0.11

 Frontal lobe

0.2 (0.5)

0.4 (0.8)

−0.55 to 0.22

0.39

 Temporal lobe

0.2 (0.5)

0.7 (1.0)

−0.9 to -0.3

0.04

 Parietal lobe

0.2 (0.5)

0.5 (0.7)

−0.64 to 0.12

0.17

 Amygdala

0.9 (1.5)

1.5 (1.8)

−1.5 to 0.5

0.29

 Transentorhinal cortex

0.6 (1.1)

1.1 (1.5)

−1.3 to 0.3

0.23

Total (all areas; score out of 15)

6.6 (2.8)

5.2 (2.3)

−0.3 to3.1

0.11

Other pathologies

 Arg

13 (37 %)

4 (27 %)

n/a

0.74

 CWMR

22 (65 %)

10 (67 %)

n/a

0.89

 CAA

16 (47 %)

10 (67 %)

n/a

0.21

 Brain neoplasms

2 (6 %)

0

n/a

1.0

 Acute infarcts

6 (18 %)

2 (13 %)

n/a

1.0