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Table 3 Semi-quantitative analyses of neuritic plaques (NP) and neurofibrillary tangles (NFT), Lewy-type synucleinopathy (listed as average (mean)), and other pathologies (listed as frequencies) within aMCI (N = 34) and naMCI (N = 15)

From: Neuropathological comparisons of amnestic and nonamnestic mild cognitive impairment

  aMCI naMCI 95 % CI p-value
Neuritic plaques     
 Frontal lobe 1.5 (1.3) 1.8 (1.3) −1.0 to 0.6 0.55
 Temporal lobe 1.5 (1.3) 1.5 (1.3) −0.7 to 0.9 0.88
 Parietal lobe 1.6 (1.3) 1.7 (1.7) −1.0 to 0.7 0.76
 Hippocampus region 0.7 (0.9) 0.7 (0.8) −0.53 to 0.53 1.00
 Entorhinal region 1.3 (1.3) 1.3 (1.0) −0.8 to 0.8 0.97
Total (all areas; score out of 15) 6.6 (5.7) 1.2 (5.2) −4.3 to 2.9 0.11
Neurofibrillary tangles     
 Braak NFT stage IV (I-VI) III (II-IV) −0.22 to 0.95 0.22
 Frontal lobe 0.4 (0.6) 0.2 (0.3) −0.06 to 0.60 0.11
 Temporal lobe 1 (0.8) 0.6 (0.7) −0.04 to 0.91 0.07
 Parietal lobe 0.4 (0.6) 0.1 (0.2) −0.02 to 0.60 0.07
 Hippocampus region 2.2 (0.9) 2.0 (0.9) −0.30 to 0.80 0.36
 Entorhinal region 2.6 (0.8) 2.5 (0.8) −0.38 to 0.60 0.66
Total (all areas; score out of 15) 6.6 (2.8) 5.2 (2.3) −0.3 to3.1 0.11
Lewy type synucleinopathy     
 Olfactory bulb 1.1 (1.6) 1.5 (1.8) −1.5 to 0.7 0.44
 Cingulate cortex 0.6 (1.1) 1.2 (1.6) −1.4 to 0.1 0.11
 Frontal lobe 0.2 (0.5) 0.4 (0.8) −0.55 to 0.22 0.39
 Temporal lobe 0.2 (0.5) 0.7 (1.0) −0.9 to -0.3 0.04
 Parietal lobe 0.2 (0.5) 0.5 (0.7) −0.64 to 0.12 0.17
 Amygdala 0.9 (1.5) 1.5 (1.8) −1.5 to 0.5 0.29
 Transentorhinal cortex 0.6 (1.1) 1.1 (1.5) −1.3 to 0.3 0.23
Total (all areas; score out of 15) 6.6 (2.8) 5.2 (2.3) −0.3 to3.1 0.11
Other pathologies     
 Arg 13 (37 %) 4 (27 %) n/a 0.74
 CWMR 22 (65 %) 10 (67 %) n/a 0.89
 CAA 16 (47 %) 10 (67 %) n/a 0.21
 Brain neoplasms 2 (6 %) 0 n/a 1.0
 Acute infarcts 6 (18 %) 2 (13 %) n/a 1.0