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Fig. 2 | BMC Neurology

Fig. 2

From: Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

Fig. 2

a. Gastrointestinal tract acid (465/403) levels in Multiple Sclerosis. Cross sectional serum samples from each of the clinical groups were subjected to lipidomic analysis utilizing tandem mass spectrometry. Bars represent the mean concentration of gastrointestinal tract acid (abbreviated as MRM 465/403). Error bars represent ± SEM. RRMS <13 Y: Relapsing Remitting Multiple Sclerosis having less than 13 years of disease duration; RRMS > = 13 Y: Relapsing Remitting Multiple Sclerosis with >= 13 years of disease duration; SPMS: Secondary Progressive Multiple Sclerosis; PPMS: Primary Progressive Multiple Sclerosis. Letters shared in common indicate no significant difference between the respective groups (P < 0.05, ANOVA followed by post hoc Sidak test of log normalized internal standard corrected analyte values). b. Correlation of gastrointestinal tract acid (465/403) to the disease duration in relapsing remitting Multiple Sclerosis. Mean concentration of gastrointestinal tract acid 465/403 in serum as measured by tandem mass spectrometry in relapsing remitting multiple sclerosis patients with the same disease duration (rounded down to years) were plotted against the disease duration. Slope of the curve that best fits the data was −0.025 and R2 = 0.2019

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