Table 2 Characteristics associated with stroke severity on hospital admission in 1013 patients with acute ischemic stroke (bivariate and multivariable analyses)
Bivariate analyses | Multivariable analysis | ||||
|---|---|---|---|---|---|
Mild to moderate stroke (NIHSS < 11) n = 769 | Severe stroke (NIHSS ≥ 11) n = 244 | p value | Probability severe stroke OR (95 % CI) | p value | |
Age in years; median (IQR) | 68.0 (59.5–77.0) | 74.0 (65.0–81.0) | <0.001 | 1.17 (1.03–1.37)* | 0.018 |
Female sex; % (n) | 44.6 (343) | 53.7 (131) | 0.013 | 1.16 (0.84–1.59) | 0.372 |
Comorbidities; % (n) | |||||
Previous stroke or TIA | 24.3 (187) | 23.0 (56) | 0.663 | ||
Atrial fibrillation | 19.1 (147) | 49.6 (121) | <0.001 | 3.43 (2.47–4.78) | <0.001 |
Diabetes | 27.8 (214) | 28.7 (70) | 0.794 | ||
Hypertension | 71.9 (553) | 71.3 (174) | 0.856 | ||
Coronary artery disease | 18.9 (145) | 30.3 (74) | <0.001 | 1.51 (1.07–2.14) | 0.020 |
Peripheral artery disease | 6.0 (46) | 6.1 (15) | 0.924 | ||
Chronic heart failure | 13.7 (105) | 25.8 (63) | <0.001 | 1.33 (0.89–1.97) | 0.161 |
Chronic inflammatory airway disease | 6.6 (51) | 8.6 (21) | 0.296 | ||
Antithrombotic medication prior to admission; % (n) | 0.631 | ||||
None | 66.8 (514) | 65.0 (158) | |||
Antiplatelets | 28.0 (215) | 31.3 (76) | |||
Anticoagulation INR < 2 | 2.6 (20) | 1.6 (4) | |||
Anticoagulation INR ≥ 2† | 2.6 (20) | 2.1 (5) | |||