Table 2 MRI and CSF findings in patients with late-onset and early-onset AQP4-seropositive NMO/NMOSD
Feature | Late-onset AQP4-Ab Positive | Early-onset AQP4-Ab Positive | p value |
|---|---|---|---|
Brain MRI, n | 28 (93.3) | 24 (80) | |
Normal | 4 (14.3) | 5 (21) | 0.398 |
Nonspecific | 15 (53.6) | 7 (29) | 0.067 |
MS-like | 1 (3.6) | 3 (12.5) | 0.249 |
NMO-like | 3 (10.7) | 10 (41.6) | 0.012 |
Spinal cord MRI, n | 28 (93.3) | 27 (90) | |
Length of spinal lesion, VBs, median | 6 (3–16) | 5 (0–19) | 0.914 |
CSF analysis | |||
CSF pleocytosis, WBC count ≥10/μL, n/total | 5/24 (20.8) | 6/24 (25) | 0.5 |
Elevated CSF protein, >0.6 g/L, n/total | 4/24 (16.7) | 3/24 (12.5) | 0.45 |
Oligoclonal bands positivity, n/total | 1/20 (5) | 2/20 (10) | 0.46 |