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Table 2 Alterations in walking performance between Time 1 and Time 2

From: Dynamic walking features and improved walking performance in multiple sclerosis patients treated with fampridine (4-aminopyridine)

(a)

Minute 1–4 (N = 35)

Statistic

Time 1

Time 2

% improvement

F

p

partial eta squared

Total distance (feet)

 Mean

758.5

935.2

23 %

49.46

<.001

.59

 SD

274.7

253.7

25-foot-walkspeed

 Mean

10.21

8.41

18 %

21.25

<.001

.39

 SE

0.77

0.52

Curvespeed

 Mean

5.55

4.50

19 %

17.34

<.001

.34

 SE

0.44

0.30

(b)

Minute 1–6 (N = 27)

Statistic

Time 1

Time 2

% improvement

F

p

Partial eta squared

Total distance (feet)

 Mean

869.0

993.6

14 %

65.82

<.001

.72

 SD

200.3

226.0

25-foot-walkspeed

 Mean

9.06

7.99

12 %

59.36

<.001

.70

 SE

0.60

0.58

Curvespeed

 Mean

4.95

4.31

13 %

77.91

<.001

.75

 SE

0.35

0.35

  1. Comparison between walking performance at Time 1 (off fampridine) and Time 2 (on fampridine), displayed for test minutes 1–4 (a) and test minutes 1–6 (b). Mean speed values reflect the duration (in seconds) necessary to cover the 25-foot distance (25-foot-walkspeed) and to circle the poles at the end of the 25-foot walk distance (Curvespeed), averaged across test minutes 1–4 and 1–6, respectively. Note that the analysis occurred separately for the respective test minutes, due to the fact that all participants managed to complete the first 4 min of the test at both assessment points (N = 35), whereas data of 27 patients was available for the entire 6 min at Time 1