Skip to main content

Table 2 Primary outcome and secondary outcomes of the HEBRAS study

From: HEart and BRain interfaces in Acute ischemic Stroke (HEBRAS) – rationale and design of a prospective oberservational cohort study

Primary outcome
 • Detection rate of pathologic findings relevant to stroke etiology in patients with acute ischemic stroke obtained by enhanced diagnostic MRI work-up combined with prolonged Holter-monitoring in comparison to findings obtained by routine diagnostic work-up.
Secondary outcomes
 • To assess the benefit of prolonged continuous ECG-monitoring in AIS patients to detect paroxysmal AF.
 • To determine the proportion of patients with first detected paroxysmal AF by prolonged Holter-monitoring (for up to 5 days) after hospital discharge.
 • To identify the impact of stroke localization on autonomic changes (as indicated by elevated urinary norepinephrine levels and measures of HRV) or cardiac dysfunction (as indicated by troponin T serum levels).
 • To identify the impact of impaired HRV on recurrent vascular events and clinical outcome after AIS at 3 or 12 months after the index stroke, respectively.
 • To assess the predictive value of imaging and biomarkers for AF-detection in patients with acute ischemic stroke.