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Fig. 3 | BMC Neurology

Fig. 3

From: Adult-onset central nervous system hemophagocytic lymphohistiocytosis: a case report

Fig. 3

Autopsy neuropathologic findings. a Representative coronal section illustrating destructive lesions involving the bilateral frontal lobes and right temporal lobe. There was significant destruction of white matter parenchyma with relative preservation of the cortex. b-c Hematoxylin and eosin sections demonstrating astrogliosis and parenchymal inflammation with numerous macrophages and emperipolesis. The arrow points to a macrophage containing a red blood cell within its cytoplasm (hemophagocytosis). d CD68 immunohistochemistry highlighting numerous macrophages with cytoplasmic punched out spaces representing emperipolesis

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