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Fig. 1 | BMC Neurology

Fig. 1

From: Immunological and short-term brain volume changes in relapsing forms of multiple sclerosis treated with interferon beta-1a subcutaneously three times weekly: an open-label two-arm trial

Fig. 1

Brain volume changes in RRMS patients vs HCs. Percent change in whole brain volume in RRMS patients treated with IFN β-1a SC tiw and in HCs was measured. No P-values remained significant after adjustment for multiple comparisons. *P < 0.05, within-group difference from zero (Wilcoxon signed-rank test). P < 0.05, patients versus HCs (Wilcoxon rank-sum test). In the box plots, the bold line represents the median; the boxes represent the middle 50 % of data; the top and bottom of the box represent the third and first quartiles; the open circles are outliers. The whisker lines above and below the boxes represent the largest and smallest values that are not considered to be outliers. Means are denoted by a ‘+’ sign. HC healthy control; IFN interferon; RRMS relapsing–remitting multiple sclerosis; SC subcutaneously; tiw three times weekly

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