| Baseline to 12 weeks | 12 to 24 weeks | Baseline to 24 weeks | |||
---|---|---|---|---|---|---|
Patients | HCs | Patients | HCs | Patients | HCs | |
n (missinga) | 23 (0) | 15 (0) | 21 (2) | 14 (1) | 21 (2) | 14 (1) |
Percent change in whole brain (%) | ||||||
 Mean (SD) | –0.95 (1.712) | 0.24 (1.068) | –0.08 (1.358) | –0.32 (1.500) | –0.91 (1.880) | 0.01 (0.885) |
 Median | –0.90 | 0.33 | 0.07 | –0.02 | –0.63 | 0.05 |
 Min, max | –4.7, 2.8 | –2.0, 1.7 | –2.8, 2.6 | –3.6, 2.2 | –5.1, 2.4 | –1.2, 1.8 |
  P valueb | 0.030 | 0.359 | 0.960 | 0.626 | 0.051 | 0.952 |
 Adjusted P-valueb,c | NS | NS | NS | NS | NS | NS |
  P-valued | 0.015 | 0.702 | 0.071 | |||
 Adjusted P-valuec,d | NS | NS | NS | |||
 Adjusted P-valuec,e | NS/NS |  | ||||
Percent change in gray matter (%) | ||||||
 Mean (SD) | –1.52 (2.406) | 0.01 (2.415) | –0.46 (3.109) | –0.60 (2.189) | –1.66 (1.836) | –0.51 (2.472) |
 Median | –1.89 | 0.80 | –1.20 | –0.72 | –1.24 | –1.31 |
 Min, max | –6.3, 2.3 | –3.7, 3.7 | –6.3, 9.4 | –4.4, 2.5 | –5.9, 1.7 | –4.5, 5.1 |
  P-valueb | 0.004 | 0.934 | 0.176 | 0.426 | <0.001 | 0.268 |
 Adjusted P-valueb,c | 0.0286 | NS | NS | NS | 0.0016 | NS |
  P-valued | 0.093 | 0.778 | 0.342 | |||
 Adjusted P-valuec,d | NS | NS | NS | |||
 Adjusted P-valuec,e | NS/NS |  | ||||
Percent change in white matter (%) | ||||||
 Mean (SD) | –0.41 (2.159) | 0.51 (1.940) | 0.30 (2.991) | –0.03 (1.985) | –0.21 (3.202) | 0.58 (2.461) |
 Median | –0.63 | 0.69 | 0.93 | 0.50 | 0.08 | 0.95 |
 Min, max | –5.4, 3.5 | –5.1, 3.0 | –6.5, 7.4 | –3.4, 2.7 | –5.9, 8.4 | –4.5, 3.6 |
  P-valueb | 0.390 | 0.107 | 0.626 | 0.952 | 0.933 | 0.463 |
 Adjusted P-valueb,c | NS | NS | NS | NS | NS | NS |
  P-valued | 0.093 | 0.630 | 0.309 | |||
 Adjusted P-valuec,d | NS | NS | NS | |||
 Adjusted P-valuec,e | NS/NS |  |