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Table 2 Demographical and clinical characteristics of SPMS patients

From: Transcriptional response to interferon beta-1a treatment in patients with secondary progressive multiple sclerosis

  Treated IFN transcriptional responders Treated IFN transcriptional non responders Untreated
N 12 8 30
Age (years) 52.4 ± 2.8 54.9 ± 1.5 51.3 ± 1.4
F (M) 10 (2) 6 (2) 18 (12)
Disease duration (years) 12.9 ± 2.1(*)(**) 22.3 ± 2.8 19.0 ± 1.5
EDSS 6.3 ± 0.2(**) 6.3 ± 0.3 7.2 ± 0.1
Time to EDSS 6 (years) 11.4 ± 2.0 13.5 ± 1.4 12.6 ± 1.3
Annual EDSS change 0.6 ± 0.1(*) 0.3 ± 0.1 0.4 ± 0.1
Relapse rate 0.8 ± 0.1(*)(**) 0.4 ± 0.04 0.4 ± 0.05
Treatment duration (years) 3.5 ± 0.8(*) 6.4 ± 1.2 NA
  1. *p <0.05 between SPMS transcriptional responders vs. non-responders
  2. **p < 0.05 between SPMS transcriptional responders vs. untreated