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Table 1 Clinical findings of cases

From: Autobiographical age awareness disturbance syndrome in autoimmune limbic encephalitis: two case reports

Case 1 2
Age 42 55
Sex Female Female
Diagnosis Anti-NMDA receptor encephalitis Anti-NMDA receptor encephalitis
Neuropsychological symptoms
 AAAD (wrong age estimation) Yes (17) Yes (27)
 Disorientation Yes Yes
 Retrograde and anterograde amnesia Yes Yes
Neuropsychological examination   
 MMSEa 15/30 26/30
 WMS-Rb
  Verbal MQ <50 94
  Visual MQ 111 97
  General MQ 71 94
  Attention/Concentration 97 79
  Delayed recognition 64 75
 WAIS-IIIb
  Verbal IQ 82 94
  Performance IQ 68 86
  Full scale IQ 72 89
Clinical examination
 CSF 20 cells/mm3 (lymphocytes predominant) with normal protein levels Normal cells, protein levels
Elevated anti-NMDA receptor antibody titres Elevated anti-NMDA receptor antibody titres
 Blood Elevated anti-NMDA receptor antibody titres Elevated anti-NMDA receptor antibody titres
 Brain MRI High intensity bilateral medial temporal lobe lesion (assessed by FLAIR) No specific findings
123I-IMP brain perfusion SPECT Increase in bilateral medial temporal lobe blood flow; decrease in right orbitofrontal region blood flow Bilateral increase in medial temporal lobe and orbitofrontal region blood flow
 EEG Sporadic spike discharge and diffuse slow waves No epileptic discharge
  1. aScore ≥ 28 points (out of 30) indicates normal cognition in their age [14]
  2. bThe index scores of the Wechsler memory scale-revised and Wechsler adult intelligence scale-III have a mean of 100, and standard deviation of 15