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Table 3 Results of CSF and serum analyses of a representative study patient

From: Transient spurious intrathecal immunoglobulin synthesis in neurological patients after therapeutic apheresis

CSF/serum biomarker [normal range]

LP before PE

LP one day after PE

CSF total protein concentration (mg/L) [<450]

451

820

CSF albumin (mg/L)/serum albumin (g/L) [110-350/35-52]

276/41.9

471/53.2

QAlb [for age 50 years: < 7.3]

6.5

8.9

CSF IgG (mg/L)/serum IgG (g/L) [14-40/7-16]

26.9/9.79

16.7/2.23

QIgG

2.7

7.4

IgG synthesis (%)

0

8.6

IgG index

0.41

0.84

CSF IgA (mg/L)/serum IgA (g/L) [1.5-6.0/0.7-4.0]

4.38/2.3

3.57/0.54

QIgA

1.9

6.6

IgA synthesis (%)

0

29.2

CSF IgM (mg/L)/serum IgM (g/L) [<1/0.4–2.3]

0.63/1.34

0.75/0.19

QIgM

0.4

4.0

IgM synthesis (%)

0

40.2

  1. Abbreviations: CSF cerebrospinal fluid, LP lumbar puncture, PE therapeutic plasma exchange, QAlb albumin quotient, IgG, IgA, and IgM immunoglobulins G, A, and M, QIgG IgG quotient, QIgA IgA quotient, QIgM IgM quotient