Table 1 Inclusion and exclusion criteria

• Newly diagnosed grade III or IV glioma

• Age ≥ 18

• Treated by radiotherapy and concomitant-adjuvant Tomozolomide as described by Stupp et al. [23] or with an abbreviated course of radiotherapy in elders patients [24]

• Treatment and clinical follow-up performed at Hôpital de la Pitié-Salpêtrière (Paris, France) or Centre de lute contre le cancer Paul Strauss (Strasbourg, France)

• History of other CNS tumor

• History of neurologic and/or psychiatric disease involving cognitive impairments (TBI, Stroke, mood and personality disorders…)

• Insufficient understanding of French language