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Table 1 Constructs to be measured within the structure of the Wilson-Cleary framework

From: Understanding and optimizing brain health in HIV now: protocol for a longitudinal cohort study with multiple randomized controlled trials

Characteristics of the individual
Age, sex, self-declared race, height, weight, education, work status, occupation, living situation, cognitive reserve indicators, coping, smoking, alcohol, drug use, healthy eating behaviour
Biological and physiological variables Symptom status Functional status Health perception Quality of life (QOL)
Nadir CD4+, current immunological markers, current viral load, peak viral load, current ARV treatment, duration of HIV infection;
Co-morbidities: diabetes, cardiovascular disease, hypercholesterolemia, hepatitis B & C, vitamin B12, thyroid-stimulation hormone (TSH), others
Physical Symptoms: vitality, pain, sleep quality, HIV related signs and symptoms Measured and self-reported cognitive deficits; cognitive ability; self-efficacy General health perception; health utility Personalized QOL; HIV-specific QOL
Emotional symptoms: anxiety, stress, depression, apathy Physical activity; physical function; self-efficacy for managing HIV health challenges
Role participation: work status, work quality, nature and frequency of leisure activities, life space mobility
Social and psychological supports
Social support, self-management priorities
  1. ARV anti-retroviral