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Fig. 6 | BMC Neurology

Fig. 6

From: Atorvastatin in improvement of cognitive impairments caused by amyloid β in mice: involvement of inflammatory reaction

Fig. 6

PI3K inhibitor had no effects on the anti-dementia, anti-inflammatory and LTP protection of ATV. a Western blot of phosphor-Akt in hippocampus in control and Aβ25–35 mice treated with ATV or FOH. *P < 0.05 vs. control mice; ## P < 0.01 vs. Aβ25–35-mice; $ P < 0.05 vs. control/ATV; ++ P < 0.01 vs. Aβ25–35/ATV (two-way ANOVA). b-d Effects of PI3K inhibitor LY294002 (LY) on the anti-dementia, anti-inflammatory and LTP protection of ATV in Aβ25–35-mice (n = 8). e-g The administration of LY294002, the effects of ATV on the microglial activation, and expressions of IL-1β and TNF-α in the Aβ25-35-treated animals were inhibited

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