Table 3 Diagnostic accuracy of DOT (cutpoint 0.297), DOT (cutpoint – 0.547) and Dawson scores on full validation cohort and cohort excluding retinal events. Confidence intervals (95 %) are shown where available
Full validation cohort (n = 525) | |||
DOT 0.297 | DOT -0.547 | Dawson | |
True positive | 192 | 210 | 197 |
False positive | 41 | 70 | 142 |
True negative | 248 | 219 | 147 |
False negative | 44 | 26 | 39 |
Sensitivity | 81 % (76 %–86 %) | 89 % (84 %–93 %) | 83 % (78 %–88 %) |
Specificity | 86 % (81 %–90 %) | 76 % (70 %–81 %) | 51 % (45 %–57 %) |
Positive predictive value | 82 % (77 %–87 %) | 75 % (70 %–80 %) | 58 % (53 %–63 %) |
Negative predictive value | 85 % (80 %–89 %) | 89 % (85 %–93 %) | 79 % (72 %–85 %) |
Positive likelihood ratio | 5.73 (4.29–7.66) | 3.67 (2.98–4.53) | 1.70 (1.49–1.94) |
Negative likelihood ratio | 0.22 (0.17–0.28) | 0.15 (0.10–0.21) | 0.32 (0.24–0.44) |
Validation cohort excluding retinal events (n = 485) | |||
DOT 0.297 | DOT -0.547 | Dawson | |
True positive | 156 | 172 | 175 |
False positive | 41 | 70 | 142 |
True negative | 248 | 219 | 147 |
False negative | 40 | 24 | 21 |
Sensitivity | 80 % (73 %–85 %) | 88 % (82 %–92 %) | 89 % (84 %–93 %) |
Specificity | 86 % (81 %–90 %) | 76 % (70 %–81 %) | 51 % (45 %–57 %) |
Positive predictive value | 79 % (73 %–85 %) | 71 % (65 %–77 %) | 55 % (50 %–61 %) |
Negative predictive value | 86 % (82 %–90 %) | 90 % (86 %–94 %) | 88 % (82 %–92 %) |
Positive likelihood ratio | 5.61 (4.19–7.51) | 3.62 (2.94–4.47) | 1.82 (1.60–2.06) |
Negative likelihood ratio | 0.24 (0.18–0.31) | 0.16 (0.11–0.24) | 0.21 (0.14–0.32) |