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Fig. 1 | BMC Neurology

Fig. 1

From: COPPADIS-2015 (COhort of Patients with PArkinson’s DIsease in Spain, 2015), a global –clinical evaluations, serum biomarkers, genetic studies and neuroimaging– prospective, multicenter, non-interventional, long-term study on Parkinson’s disease progression

Fig. 1

Recruitment period, from November 2015 to February 2017 (baseline assessment of each participating subject). 1, patient inclusion process and motor assessment by the Principal Investigator (neurologist who is an expert in movement disorders and Parkinson’s disease); 2a, non-motor assessment by the Principal Investigator, specialized nurse, psychologist or fellow with adequate training; 2b, caregiver assessment; 2c, control assessment. *Only patients with motor fluctuations (UPDRS-IV) will be assessed during the OFF-medication (first thing in the morning without taking medication in the 12 previous hours) and during the ON-medication state; the rest will only be assessed during the OFF-medication state. Blood samples from the baseline assessment will be stored for the purpose of being able to test other future markers not currently included in the project

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