Table 3 Primary Endpoints

Absolute and relative change from baseline of the following cell counts in the peripheral blood at indicated time points of sampling (see Additional file 1: Assessment Schedule):

a. T cell subsets:

 - CD4 and CD8 positive T cells: naïve T cells, T effector cells, T memory cells, regulatory T cells

 - T-helper subsets: T_h 1, T_h 2, T_h 17

b. B cell subsets:

 - Recent bone marrow emigrants, mature naïve, memory B cells

 - Plasma cells

c. Natural killer cells:

 - CD56bright, CD56dim

 - Natural killer T cells

d. Antigen-Presenting cells:

 - Dendritic cells: CD303⁺ plasmacytoid, CD11c⁺ and CD141⁺ myeloid dendritic cells

 - Monocytes and macrophages (non-classical CD14⁺CD16⁺⁺HLA-DR⁺⁺, classical CD14⁺⁺CD16⁻HLA-DR⁺)

e. Myeloid-derived suppressor cells.