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Fig. 3 | BMC Neurology

Fig. 3

From: The value of early and comprehensive diagnoses in a human fetus with hydrocephalus and progressive obliteration of the aqueduct of Sylvius: Case Report

Fig. 3

The human subcommissural organ (SCO). a Line drawing of a human brain showing the location of the SCO (red rectangle). b Sagittal section through the epithalamus of a 32 GW human embryo (for orientation see rectangle in previous figure) showing the SCO, posterior commissure (pm), pineal gland (P), third ventricle (3°) and SA. Inset. Ependyma of a human SCO (see frame in B), immunostained for SCO-spondin. Scale bar B 350 µm, inset 50 µm. c Histograms of microdensitometric recordings of immunoblots with anti-P15, shown in (d). d Immunoblots of CSF samples from the hydrocephalic case and from a 33rd GW fetus with an arachnoid cyst, using anti-P15 and anti-hSCO antisera. Blue arrows point to compounds present in the hydrocephalic CSF and missing in the control; red arrows indicate compounds that are present in the control but missing or at lower concentration in the hydrocephalic CSF. e Histograms of microdensitometric recording of immunoblots with anti-P15, shown in (d). Control, CSF obtained by lumbar puncture from a patient 9 months old diagnosed with leukemia symptoms but no ventriculomegaly

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