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Table 1 Univariate Analysis comparing patients with favorable (mRS 0–2 or unchanged) and unfavorable outcome. Displayed as median with interquartile range in parentheses or percentage

From: Time-dependent parameter of perfusion imaging as independent predictor of clinical outcome in symptomatic carotid artery stenosis

  Favorable outcome (n = 23) Unfavorable outcome (n = 9) p-value
Age 70 (63;74) 79 (74;84) 0.001
Men 74 % 89 % 0.357
Degree of Stenosis in % 80 (70;90) 80 (70;90) 0.536
Risk Factors    
 -atrial fibrillation 4 % 22 % 0.119
 -peripheral artery disease 17 % 11 % 0.660
 -coronary heart disease 22 % 22 % 0.976
 -smoking 39 % 11 % 0.124
 -hypercholesterolemia 48 % 67 % 0.337
 -hypertension 83 % 67 % 0.370
 -diabetes 17 % 67 % 0.007
Treatment with Alteplase 9 % 11 % 0.833
Treatment with TEA or CAS 96 % 67 % 0.026
Time from symptom onset to MRI    0.884
 -<24 h 57 % 78 %  
 -24–48 h 13 % 11 %  
 -48–72 h 4 % 0 %  
 ->72 h 26 % 11 %  
Time to intervention (days) 4.0 (1.5;7.0) 1.5 (0.0;3.8) 0.085
Length of stay in hospital 7 (7;9) 6 (4;11) 0.711
NIHSS score    
 -on admission 3 (1;5) 8 (5;13) 0.002
 -at discharge 1 (0;2) 13 (5;14) ≤0.001
Premorbid mRS Score 2 (0;2) 1 (1;2) 0.965
TCD    
 -SF (kHz) 2.15 (1.65;2.40) 1.70 (1.30;2.10) 0.148
 -DF (kHz) 0.75 (0.60;1.05) 0.55 (0.43;0.83) 0.122
 -Mean (kHz) 1.13 (1.00;1.53) 0.93 (0.72;1.25) 0.148
 -contralateral SF (kHz) 1.95 (1.70;2.78) 1.6 (1.6; 1.6) 0.634
 -contralateral DF (kHz) 0.80 (0.60;0.90) 0.6 (0.3;0.6) 0.559
 -mean contralateral (kHz) 1.17 (0.95;1.53) 0.93 (0.73;0.93) 0.559
 -reduced acceleration at MCA 26 % 22 % 0.531
 -RI 0.59 (0.56;0.67) 0.65 (0.58;0.71) 0.249
 -Contralateral RI 0.66 (0.57;0.71) 0.66 (0.63;0.66) 0.712
TTP volume (ml)    
 -TTP visual 78.50 (0.00;189.50) 111.40 (0.00; 232..40) 0.112
 -TTP ≥2 s 18.50 (0.00;41.19) 29.77 (5.18;132.89) 0.003
 -TTP ≥4 s 0.87 (0.00;4.05) 9.12 (2.19;66.86) 0.043
 -TTP ≥6 s 0.20 (0.00;0.89) 6.70 (1.07;37.48) 0.017
Tmax volume (ml)    
 -Tmax ≥4 s 0.00 (0.00;13.52) 25.27 (1.17;110.40) 0.043
 -Tmax ≥6 s 0.00 (0.00;1.10) 9.21 (0.72;44.94) 0.017
 -Tmax ≥8 s 0.00 (0.00;0.66) 6.86 (0.56;23.47) 0.011
 -Tmax ≥10s 0.00 (0.00;0.54) 5.94 (0.56; 23.47) 0.019
DWI lesion volume (ml) 2.45 (0.14;9.73) 18.04 (8.80; 24.41) 0.001
  1. TEA thromboendarterectomy, CAS carotid artery stenting, MRI magnetic resonance imaging, NIHSS National Institute of Health Stroke Scale, mRS modified Rankin scale, TCD transcranial dopplersonography, MCA middle cerebral artery, RI resistance index, TTP time-to-peak, T max time to maximum of residual curve