Table 2 Clinical and radiological outcomes in patients with IAT for acute ischemic stroke caused by proximal arterial intracranial occlusion of the anterior circulation by age
Overall | Tertile 1 | Tertile 2 | Tertile 3 | P for trend | |
|---|---|---|---|---|---|
22–93 years | 22–55 years | 56–70 year | 71–93 years | ||
N patients | 315 | 106 | 113 | 96 | |
Procedural duration in minutes, median (IQR) | 116 | 125 | 110 | 116 | 0.19 |
(80–153) | (81–160) | (78–143) | (82–158) | ||
Recanalization (TICI 2b and TICI 3) | 119 (43 %) | 41 (34 %) | 45 (38 %) | 33 (28 %) | 0.46 |
TICI 0, n (%) | 38 (14 %) | 12 (12 %) | 12 (12 %) | 14 (17 %) | |
TICI 1, n (%) | 18 (6.0 %) | 10 (10 %) | 5 (5.0 %) | 3 (4.0 %) | |
TICI 2a, n (%) | 103 (37 %) | 36 (36 %) | 35 (36 %) | 32 (39 %) | |
TICI 2b, n (%) | 36 (13 %) | 13 (13 %) | 17 (18 %) | 6 (7.0 %) | |
TICI 3, n (%) | 83 (30 %) | 28 (28 %) | 28 (29 %) | 27 (33 %) | |
NIHSS after IAT, mean (SD) | 13 (12) | 12 (10) | 13 (11) | 15 (13) | 0.14 |
Neurological recovery (decrease in NIHSS of 8 points or more), n (%) | 133 (42 %) | 47 (44 %) | 49 (43 %) | 37 (39 %) | |
Functional outcome, mRS, n (%) | 0.03 | ||||
mRS 0–1, n (%) | 37 (12 %) | 15 (14 %) | 9 (8 %) | 13 (14 %) | |
mRS 0–2, n (%) | 78 (25 %) | 29 (27 %) | 27 (24 %) | 22 (23 %) | |
mRS 0–3, n (%) | 132 (42 %) | 46 (43 %) | 49 (43 %) | 37 (39 %) | |
mRS 0–4, n (%) | 222 (70 %) | 80 (75 %) | 82 (73 %) | 60 (63 %) | |
mRS 0–5, n (%) | 261 (83 %) | 96 (91 %) | 92 (81 %) | 73 (76 %) | |
Death, n (%) | 51 (16 %) | 10 (9 %) | 20 (18 %) | 21 (22 %) | 0.01 |
All adverse events, n (%) | 177 (56 %) | 46 (43 %) | 71 (63 %) | 60 (63 %) | 0.004 |
Serious adverse events, n (%) | 47 (15 %) | 13 (12 %) | 18 (16 %) | 16 (17 %) | 0.11 |
Symptomatic intracranial hemorrhage, n (%) | 23 (7.0 %) | 5 (5.0 %) | 8 (7.0 %) | 10 (10 %) | |
Hemorrhagic transformation infarct, n (%) | 6 (2.0 %) | 2 (2.0 %) | 4 (4.0 %) | 0 (0.0 %) | |
Progression of ischemic stroke, n (%) | 32 (10 %) | 8 (8.0 %) | 13 (12 %) | 11 (12 %) | |
Neurological adverse events, n (%) | 119 (38 %) | 38 (36 %) | 48 (42 %) | 33 (34 %) | 0.60 |
Asymptomatic intracranial hemorrhage | 22 (7 %) | 2 (2.0 %) | 15 (13 %) | 5 (5.0 %) | |
hemorrhage, n (%) | |||||
Seizures, n (%) | 16 (5.0 %) | 4 (4.0 %) | 4 (4.0 %) | 8 (8.0 %) | |
Non-neurological adverse events, n (%) | 101 (32 %) | 20 (19 %) | 40 (35 %) | 41 (43 %) | 0.002 |
Pneumonia, n (%) | 41 (13 %) | 9 (8.0 %) | 16 (14 %) | 16 (17 %) | |
Urinary tract infection, n (%) | 18 (6.0 %) | 5 (5.0 %) | 5 (4.0 %) | 8 (8.0 %) | |
Cardiac arrhythmias, n (%) | 35 (11 %) | 3 (3.0 %) | 17 (15 %) | 15 (16 %) | |
Other, n (%) | 29 (9.0 %) | 8 (8.0 %) | 9 (8.0 %) | 12 (13 %) |