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Table 2 Clinical and radiological outcomes in patients with IAT for acute ischemic stroke caused by proximal arterial intracranial occlusion of the anterior circulation by age

From: The effect of age on outcome after intra-arterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

  Overall Tertile 1 Tertile 2 Tertile 3 P for trend
22–93 years 22–55 years 56–70 year 71–93 years
N patients 315 106 113 96  
Procedural duration in minutes, median (IQR) 116 125 110 116 0.19
(80–153) (81–160) (78–143) (82–158)
Recanalization (TICI 2b and TICI 3) 119 (43 %) 41 (34 %) 45 (38 %) 33 (28 %) 0.46
 TICI 0, n (%) 38 (14 %) 12 (12 %) 12 (12 %) 14 (17 %)
 TICI 1, n (%) 18 (6.0 %) 10 (10 %) 5 (5.0 %) 3 (4.0 %)
 TICI 2a, n (%) 103 (37 %) 36 (36 %) 35 (36 %) 32 (39 %)
 TICI 2b, n (%) 36 (13 %) 13 (13 %) 17 (18 %) 6 (7.0 %)
 TICI 3, n (%) 83 (30 %) 28 (28 %) 28 (29 %) 27 (33 %)
NIHSS after IAT, mean (SD) 13 (12) 12 (10) 13 (11) 15 (13) 0.14
Neurological recovery (decrease in NIHSS of 8 points or more), n (%) 133 (42 %) 47 (44 %) 49 (43 %) 37 (39 %)
Functional outcome, mRS, n (%)      0.03
 mRS 0–1, n (%) 37 (12 %) 15 (14 %) 9 (8 %) 13 (14 %)
 mRS 0–2, n (%) 78 (25 %) 29 (27 %) 27 (24 %) 22 (23 %)
 mRS 0–3, n (%) 132 (42 %) 46 (43 %) 49 (43 %) 37 (39 %)
 mRS 0–4, n (%) 222 (70 %) 80 (75 %) 82 (73 %) 60 (63 %)
 mRS 0–5, n (%) 261 (83 %) 96 (91 %) 92 (81 %) 73 (76 %)
Death, n (%) 51 (16 %) 10 (9 %) 20 (18 %) 21 (22 %) 0.01
All adverse events, n (%) 177 (56 %) 46 (43 %) 71 (63 %) 60 (63 %) 0.004
Serious adverse events, n (%) 47 (15 %) 13 (12 %) 18 (16 %) 16 (17 %) 0.11
 Symptomatic intracranial hemorrhage, n (%) 23 (7.0 %) 5 (5.0 %) 8 (7.0 %) 10 (10 %)
 Hemorrhagic transformation infarct, n (%) 6 (2.0 %) 2 (2.0 %) 4 (4.0 %) 0 (0.0 %)
 Progression of ischemic stroke, n (%) 32 (10 %) 8 (8.0 %) 13 (12 %) 11 (12 %)
Neurological adverse events, n (%) 119 (38 %) 38 (36 %) 48 (42 %) 33 (34 %) 0.60
 Asymptomatic intracranial hemorrhage 22 (7 %) 2 (2.0 %) 15 (13 %) 5 (5.0 %)
 hemorrhage, n (%)
 Seizures, n (%) 16 (5.0 %) 4 (4.0 %) 4 (4.0 %) 8 (8.0 %)
Non-neurological adverse events, n (%) 101 (32 %) 20 (19 %) 40 (35 %) 41 (43 %) 0.002
 Pneumonia, n (%) 41 (13 %) 9 (8.0 %) 16 (14 %) 16 (17 %)
 Urinary tract infection, n (%) 18 (6.0 %) 5 (5.0 %) 5 (4.0 %) 8 (8.0 %)
 Cardiac arrhythmias, n (%) 35 (11 %) 3 (3.0 %) 17 (15 %) 15 (16 %)
 Other, n (%) 29 (9.0 %) 8 (8.0 %) 9 (8.0 %) 12 (13 %)