The effect of age on outcome after intra-arterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

BMC Neurology

Table 3 Age in association with clinical neurological and radiological outcomes. Effect parameters are expressed per 10 years of age

	Association	Unadjusted	Sex adjusted	Fully adjusted
Intervention
Duration of procedure, minutes	BC	−2.80	−2.80	−2.96
Duration of procedure, minutes	BC	[−7.10 to 1.45]	[−7.10 to 1.45]	[−7.35 to 1.44]
Recanalization (TICI 2b-3)	OR	0.94	0.94	0.94
Recanalization (TICI 2b-3)	OR	[0.80 to 1.11]	[0.8. to 1.11]	[0.79 to 1.11]
Clinical outcome
Neurological recovery (decrease on NIHSS > 7 points)	OR	0.92	0.92	0.88
Neurological recovery (decrease on NIHSS > 7 points)	OR	[0.79 to 1.08]	[0.79 to 1.08]	[0.75 to 1.04]
Functional outcome, mRS 0-2	OR	0.85	0.85	0.80
Functional outcome, mRS 0-2	OR	[0.71 to 1.01]	[0.71 to 1.01]	[0.66 to 0.98]
Safety outcome
Peri-procedural adverse events	OR	0.79	0.79	0.79
Peri-procedural adverse events	OR	[0.67 to 0.93]	[0.67 to 0.93]	[0.66 to 0.94]
All adverse events	OR	1.27	1.27	1.27
All adverse events	OR	[1.08 to 1.49]	[1.08 to 1.49]	[1.08 to 1.50]
Neurological serious adverse events	OR	1.04	1.04	1.05
Neurological serious adverse events	OR	[0.89 to 1.22]	[0.89 to 1.22]	[0.89 to 1.24]
Neurological adverse events	OR	1.04	1.04	1.05
Neurological adverse events	OR	[0.89 to 1.22]	[0.89 to 1.22]	[0.89 to 1.24]
Non-neurological adverse events	OR	1.37	1.37	1.34
Non-neurological adverse events	OR	[1.14 to 1.64]	[1.14 to 1.64]	[1.11 to 1.61]

BC beta coefficient, OR odds ratio. Fully adjusted means adjusted for; sex, onset to treatment time, stroke severity at baseline (NIHSS), use of a retrievable stent, presence of a carotid T occlusion

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