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Table 3 Methods used to deal with missing primary outcome data in included published randomised controlled trials

From: A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer’s disease and Parkinson’s disease

Method used to deal with missing data Frequency of use in RCTs in:
Alzheimer’s disease (n = 47) Parkinson’s disease (n = 31)
n % n %
Complete-case analysis 14 30 11 35
Survival analysis 3 6 10 32
Last observation carried forward 16 34 6 19
Mixed model 18 38 4 13
Data imputation 7 15 4 13
  1. Twelve AD trials did not report any information regarding how missing data was dealt with, four used two methods and two used three methods and one used four methods. Five Parkinson’s disease trials did not report any information regarding how missing data was dealt with and four used two methods