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Table 5 Prediction models of EDSS (model 1) and annual EDSS progression (model 2) from baseline data

From: Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis

 

Model 1

Model 2

EDSS

EDSS progression/year

(n=100, R2=0.72)

(n=100, R2=0.21)

Baseline Predictor

Regression coefficient ± SE

p-value

Regression coefficient ± SE

p-value

Intercept

2.8 ± 3.3

0.39

0.33 ± 0.59

0.58

Age (yrs)

−0.0033 ± 0.014

0.81

−0.00001 ± 0.0025

0.99

Height (cm)

−0.015 ± 0.021

0.48

−0.0015 ± 0.0038

0.69

Weight (kg)

−0.0059 ± 0.0098

0.55

−0.0015 ± 0.0018

0.39

Sex (1= male)

0.090 ± 0.31

0.77

0.028 ± 0.056

0.62

Laterality (1=left)

−0.066 ± 0.38

0.86

−0.046 ± 0.070

0.52

Phenotype (1 = SP or PP)

0.39 ± 0.46

0.40

0.010 ± 0.083

0.90

Disease duration (yrs)

0.0054 ± 0.016

0.73

0.0027 ± 0.0029

0.35

Follow-up duration (yrs)

0.036 ± 0.046

0.43

NA

NA

DMT (1 = yes)

0.18 ± 0.37

0.63

0.057 ± 0.066

0.39

EDSS

0.75 ± 0.13

<0.0001

−0.035 ± 0.025

0.16

EP Score

0.082 ± 0.018

<0.0001

0.012 ± 0.0034

0.0006

  1. EDSS expanded disability status scale; R 2 multiple determination coefficient, SE standard error, SP secondary progressive, PP primary progressive, DMT disease-modifying therapy during the follow-up, EP evoked potentials, NA not applicable. Baseline predictors with p-value < 0.05 are highlighted in bold