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Table 6 Prediction model of EDSS worsening from baseline data

From: Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis

 

Model 3 EDSS worsening (n=100, AUC=0.84)

Baseline Predictor

Coefficient ± SE

p-value

OR (95 % CI)

Intercept

−0.87 ± 8.4

0.92

 

Age (yrs)

0.0016 ± 0.035

0.97

 

Height (cm)

−0.032 ± 0.053

0.55

 

Weight (kg)

0.0057 ± 0.027

0.83

 

Sex (1= male)

0.34 ± 0.79

0.67

 

Laterality (1=left)

−0.34 ± 0.99

0.73

 

Phenotype (1 = SP or PP)

0.78 ± 1.2

0.53

 

Disease duration (yrs)

0.12 ± 0.048

0.01

 

Follow-up duration (yrs)

0.029 ± 0.12

0.82

 

DMT (1 = yes)

3.1 ± 1.6

0.05

 

EDSS

−0.42 ± 0.36

0.24

0.66 (0.32–1.3)

EP Score

0.18 ± 0.054

0.0012

1.2 (1.1–1.3)

  1. EDSS expanded disability status scale, AUC area under the ROC Curve, OR odds Ratio, CI confidence interval, EP evoked potentials, EDSS worsening, 1-point increase from T0 to T1 given a baseline EDSS <5.5 or an increase of 0.5 point given a baseline EDSS ≥ 5.5; DMT, disease-modifying therapy during the follow-up. Baseline predictors with p-value < 0.01 are highlighted in bold
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BMC Neurology

ISSN: 1471-2377

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