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Table 6 Prediction model of EDSS worsening from baseline data

From: Multimodal evoked potentials for functional quantification and prognosis in multiple sclerosis

  Model 3 EDSS worsening (n=100, AUC=0.84)
Baseline Predictor Coefficient ± SE p-value OR (95 % CI)
Intercept −0.87 ± 8.4 0.92  
Age (yrs) 0.0016 ± 0.035 0.97  
Height (cm) −0.032 ± 0.053 0.55  
Weight (kg) 0.0057 ± 0.027 0.83  
Sex (1= male) 0.34 ± 0.79 0.67  
Laterality (1=left) −0.34 ± 0.99 0.73  
Phenotype (1 = SP or PP) 0.78 ± 1.2 0.53  
Disease duration (yrs) 0.12 ± 0.048 0.01  
Follow-up duration (yrs) 0.029 ± 0.12 0.82  
DMT (1 = yes) 3.1 ± 1.6 0.05  
EDSS −0.42 ± 0.36 0.24 0.66 (0.32–1.3)
EP Score 0.18 ± 0.054 0.0012 1.2 (1.1–1.3)
  1. EDSS expanded disability status scale, AUC area under the ROC Curve, OR odds Ratio, CI confidence interval, EP evoked potentials, EDSS worsening, 1-point increase from T0 to T1 given a baseline EDSS <5.5 or an increase of 0.5 point given a baseline EDSS ≥ 5.5; DMT, disease-modifying therapy during the follow-up. Baseline predictors with p-value < 0.01 are highlighted in bold