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PRISM II: an open-label study to assess effectiveness of dextromethorphan/quinidine for pseudobulbar affect in patients with dementia, stroke or traumatic brain injury

  • Flora M. Hammond1Email author,
  • David N. Alexander2,
  • Andrew J. Cutler3,
  • Stephen D’Amico4,
  • Rachelle S. Doody5,
  • William Sauve6,
  • Richard D. Zorowitz7,
  • Charles S. Davis8,
  • Paul Shin9,
  • Fred Ledon9,
  • Charles Yonan9,
  • Andrea E. Formella9 and
  • Joao Siffert9
BMC NeurologyBMC series – open, inclusive and trusted201616:89

Received: 22 December 2015

Accepted: 23 May 2016

Published: 9 June 2016

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Open Peer Review reports

Pre-publication versions of this article are available by contacting

Original Submission
22 Dec 2015 Submitted Original manuscript
12 Jan 2016 Reviewed Reviewer Report - M-Alain Babi
6 Feb 2016 Reviewed Reviewer Report - Michael Borich
16 Mar 2016 Author responded Author comments - Flora Hammond
Resubmission - Version 2
16 Mar 2016 Submitted Manuscript version 2
3 May 2016 Author responded Author comments - Flora Hammond
Resubmission - Version 3
3 May 2016 Submitted Manuscript version 3
23 May 2016 Editorially accepted
9 Jun 2016 Article published 10.1186/s12883-016-0609-0

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting

You can find further information about the peer review system here.

Authors’ Affiliations

Physical Medicine and Rehabilitation, Indiana University School of Medicine, Rehabilitation Hospital of Indiana, Indianapolis, USA
University of California, Los Angeles, USA
Florida Clinical Research Center, LLC, Bradenton, USA
Cornerstone Medical Group, Franklin, USA
Baylor College of Medicine, Houston, USA
TMS NeuroHealth Centers, Richmond, USA
MedStar National Rehabilitation Network, Washington, DC, USA
CSD Biostatistics, Inc., Tucson, USA
Avanir Pharmaceuticals, Inc., Aliso Viejo, USA