Table 2 a-c Regression models predicting reserve-related activitiesa
Dependent Variable: | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
2a Past Reserve Building Activities | 2b Strenuous Current reserve-related Activities | 2c Non-Strenuous Current reserve-related Activities | |||||||||
Predictors | β | t | p | Predictors | β | t | p | Predictors | β | t | p |
Chronic lesion burden models | |||||||||||
Age | 0.01 | 0.13 | 0.90 | Age | –0.19 | –3.94 | 0.00 | Age | –0.05 | –0.94 | 0.35 |
Gender | –0.02 | –0.42 | 0.68 | Gender | –0.07 | –1.72 | 0.09 | Gender | –0.05 | –1.07 | 0.29 |
Chronic Burden | –0.31 | –1.25 | 0.21 | Chronic Burden | –0.34 | –1.46 | 0.15 | Chronic Burden | 0.20 | 0.82 | 0.41 |
CIS | 0.01 | 0.08 | 0.94 | CIS | –0.37 | –5.04 | 0.00 | CIS | –0.03 | –0.43 | 0.67 |
RR | –0.03 | –0.24 | 0.81 | RR | –0.51 | –5.33 | 0.00 | RR | 0.09 | 0.87 | 0.38 |
PMS | –0.14 | –1.37 | 0.17 | PMS | –0.51 | –5.42 | 0.00 | PMS | 0.13 | 1.32 | 0.19 |
Chronic X CIS | 0.01 | 0.18 | 0.86 | Chronic X CIS | 0.15 | 2.58 | 0.01 | Chronic X CIS | 0.06 | 1.05 | 0.29 |
Chronic X RR | 0.17 | 0.85 | 0.39 | Chronic X RR | 0.26 | 1.41 | 0.16 | Chronic X RR | –0.14 | –0.70 | 0.49 |
Chronic X SPMS | 0.30 | 1.42 | 0.16 | Chronic X SPMS | 0.30 | 1.51 | 0.13 | Chronic X SPMS | –0.17 | –0.83 | 0.41 |
Adjusted R-squared | 0.00 | Adjusted R-squared | 0.10 | Adjusted R-squared | 0.00 | ||||||
N | 523 | N | 526 | N | 535 | ||||||
Active lesion burden models | |||||||||||
Age | 0.00 | –0.09 | 0.93 | Age | –0.18 | –3.83 | 0.00 | Age | –0.07 | –1.40 | 0.16 |
Gender | –0.01 | –0.33 | 0.74 | Gender | –0.08 | –1.84 | 0.07 | Gender | –0.04 | –0.88 | 0.38 |
Active Burden | –0.04 | 0.00 | 1.00 | Active Burden | –11.72 | –0.89 | 0.38 | Active Burden | –4.71 | –0.34 | 0.73 |
CIS | –0.09 | –0.81 | 0.42 | CIS | –0.48 | –4.95 | 0.00 | CIS | –0.10 | –0.99 | 0.32 |
RR | –0.17 | –1.09 | 0.28 | RR | –0.75 | –5.39 | 0.00 | RR | –0.10 | –0.67 | 0.50 |
PMS | –0.22 | –1.55 | 0.12 | PMS | –0.73 | –5.59 | 0.00 | PMS | –0.03 | –0.25 | 0.81 |
Active X CIS | 0.01 | 0.00 | 1.00 | Active X CIS | 2.81 | 0.9 | 0.37 | Active X CIS | 1.02 | 0.34 | 0.73 |
Active X RR | 0.01 | 0.00 | 1.00 | Active X RR | 11.42 | 0.89 | 0.38 | Active X RR | 4.56 | 0.34 | 0.73 |
Active X SPMS | –0.02 | –0.03 | 0.97 | Active X SPMS | 0.51 | 0.84 | 0.40 | Active X SPMS | 0.15 | 0.24 | 0.81 |
Adjusted R-squared | –0.01 | Adjusted R-squared | 0.09 | Adjusted R-squared | 0.00 | ||||||
N | 504 | N | 505 | N | 514 | ||||||
Brain volume models | |||||||||||
Age | 0.03 | 0.66 | 0.51 | Age | –0.13 | –3.12 | 0.00 | Age | 0.03 | 0.55 | 0.58 |
Gender | –0.02 | –0.52 | 0.60 | Gender | 0.01 | 0.45 | 0.65 | Gender | –0.01 | –0.32 | 0.75 |
Brain Volume* | 0.09 | 1.00 | 0.32 | Brain Volume* | 0.22 | 3.08 | 0.00 | Brain Volume* | 0.10 | 1.16 | 0.25 |
White Matter Vol. | –0.01 | –0.09 | 0.93 | White Matter Vol. | 0.11 | 1.40 | 0.16 | White Matter Vol. | –0.10 | –1.02 | 0.31 |
CIS | 0.19 | 0.22 | 0.82 | CIS | 0.92 | 1.26 | 0.21 | CIS | 0.32 | 0.39 | 0.70 |
RR | –0.86 | –1.13 | 0.26 | RR | 0.98 | 1.59 | 0.11 | RR | –0.45 | –0.60 | 0.55 |
SPMS | 0.72 | 0.97 | 0.33 | SPMS | 1.20 | 1.98 | 0.05 | SPMS | –1.09 | –1.50 | 0.13 |
Brain Vol X CIS | –0.31 | –0.57 | 0.57 | Brain Vol X CIS | –0.61 | –1.34 | 0.18 | Brain Vol X CIS | –0.12 | –0.23 | 0.82 |
Brain Vol X RR | –0.04 | –0.09 | 0.93 | Brain Vol X RR | –1.01 | –2.58 | 0.01 | Brain Vol X RR | 0.06 | 0.13 | 0.90 |
Brain Vol X SPMS | –0.71 | –1.47 | 0.14 | Brain Vol X SPMS | –0.78 | –1.98 | 0.05 | Brain Vol X SPMS | –0.18 | –0.38 | 0.70 |
WMV X CIS | 0.11 | 0.16 | 0.87 | WMV X CIS | –0.60 | –0.97 | 0.33 | WMV X CIS | –0.25 | –0.40 | 0.69 |
WMV X RR | 0.86 | 1.25 | 0.21 | WMV X RR | –0.44 | –0.78 | 0.44 | WMV X RR | 0.35 | 0.52 | 0.61 |
WMV X SPMS | –0.12 | –0.20 | 0.84 | WMV X SPMS | –0.77 | –1.60 | 0.11 | WMV X SPMS | 1.25 | 2.19 | 0.03 |
Adjusted R-squared | 0.01 | Adjusted R-squared | 0.28 | Adjusted R-squared | 0.00 | ||||||
N | 732 | N | 759 | N | 757 | ||||||
Subcortical gray matter volume models | |||||||||||
Age | 0.03 | 0.74 | 0.46 | Age | –0.15 | –4.11 | 0.00 | Age | –0.01 | –0.19 | 0.85 |
Gender | –0.02 | –0.43 | 0.67 | Gender | 0.02 | 0.70 | 0.49 | Gender | –0.01 | –0.38 | 0.71 |
Subcortical Health* | 0.12 | 1.10 | 0.27 | Subcortical Health* | 0.35 | 4.01 | 0.00 | Subcortical Health* | 0.01 | 0.11 | 0.91 |
Amygdala Vol. | –0.02 | –0.27 | 0.78 | Amygdala Vol. | –0.16 | –2.39 | 0.02 | Amygdala Vol. | 0.06 | 0.81 | 0.42 |
CIS | 0.00 | –0.01 | 1.00 | CIS | 0.60 | 1.26 | 0.21 | CIS | –0.27 | –0.45 | 0.65 |
RR | –0.27 | –0.47 | 0.64 | RR | 0.37 | 0.81 | 0.42 | RR | –0.03 | –0.05 | 0.96 |
SPMS | 0.37 | 0.72 | 0.47 | SPMS | 0.48 | 1.18 | 0.24 | SPMS | 0.05 | 0.11 | 0.91 |
Subcortical X CIS | 0.04 | 0.06 | 0.95 | Subcortical X CIS | –1.03 | –2.07 | 0.04 | Subcortical X CIS | 0.22 | 0.37 | 0.71 |
Subcortical X RR | 0.16 | 0.27 | 0.79 | Subcortical X RR | –1.57 | –3.43 | 0.00 | Subcortical X RR | 0.24 | 0.44 | 0.66 |
Subcortical X SPMS | –0.64 | –1.26 | 0.21 | Subcortical X SPMS | –1.29 | –3.12 | 0.00 | Subcortical X SPMS | –0.03 | –0.06 | 0.95 |
Amygdala X CIS | –0.06 | –0.17 | 0.87 | Amygdala X CIS | 0.15 | 0.52 | 0.61 | Amygdala X CIS | –0.01 | –0.04 | 0.97 |
Amygdala X RR | 0.08 | 0.22 | 0.83 | Amygdala X RR | 0.77 | 2.70 | 0.01 | Amygdala X RR | –0.27 | –0.79 | 0.43 |
Amygdala X SPMS | 0.19 | 0.58 | 0.56 | Amygdala X SPMS | 0.48 | 1.83 | 0.07 | Amygdala X SPMS | –0.04 | –0.12 | 0.90 |
Adjusted R-squared | 0.01 | Adjusted R-squared | 0.29 | Adjusted R-squared | –0.01 | ||||||
N | 731 | N | 758 | N | 756 | ||||||