Table 1 Clinical, neuropsychological and biological assessments for the patient
From: Case report of Lewy body disease mimicking Creutzfeldt-Jakob disease in a 44-year-old man
M0 | M2 | M7 | M15 | M27 | M43 | ||
|---|---|---|---|---|---|---|---|
Neuropsychological assessment | |||||||
Global cognitive state | |||||||
MMSE | 25 | 25 | 24 | 21 | 17 | 13 | |
Speed processing | |||||||
TMT part A, time (seconds) | 133 | 157 | 144 | 193 | NA | NA | |
Short term memory | |||||||
WAIS III digit span forward | 4 | 5 | 5 | 5 | 3 | NA | |
WAIS III digit span backward | 3 | 3 | 2 | 3 | 2 | NA | |
Executive functions | |||||||
Phonemic verbal fluency: letter ‘p’ | 12 | 1 | 6 | 10 | NA | NA | |
Semantic verbal fluency: ‘animal’ category | 15 | 16 | 16 | 12 | NA | NA | |
FAB (/18) | 12 | 12 | 12 | 10 | 6 | 2 | |
TMT part B, time (seconds) | 296 | 537 | 486 | NA | NA | NA | |
TMT part B, mistakes | 0 | 1 (help) | 1 | ||||
Anterograde verbal memory | |||||||
FCSRT | |||||||
sum of free recalls (/48) | 19 | 18 | 27 | 22 | 8 | NA | |
sum of free + cued recalls (/48) | 42 | 47 | 46 | 45 | NA | NA | |
recognition (/48) | 47 | 48 | 48 | 45 | NA | NA | |
delayed free recall (/16) | 9 | 6 | 8 | 6 | NA | NA | |
delayed free + cued recall (/16) | 14 | 14 | 16 | 15 | NA | NA | |
Anterograde visual memory | |||||||
Rey complex figure, memory (/36) | < centile 10 | - | - | - | NA | NA | |
Language | |||||||
DO80 (/80) | - | - | 60 | - | NA | NA | |
Visuoconstructive praxies | |||||||
Rey complex figure, copy (/36) | 25 | 12 | 13.5 | - | NA | NA | |
EEG | |||||||
Slow cerebral activity No epileptic or pseudo-periodic abnormalities | - | PSWC discharges during hyperpnea | unchanged | - | - | ||