Skip to main content

Table 1 Parameters of the Conditioned Pain Modulation (CPM) assessment

From: Short-term test-retest-reliability of conditioned pain modulation using the cold-heat-pain method in healthy subjects and its correlation to parameters of standardized quantitative sensory testing

       t-test (p)a Intraclass correlation coefficientb
  day 1 day 2 day 1 vs. day 2
TS temperature rated with NRS 60 (°C) total 47.5 ± 1.1 (45…49) 47.5 ± 1.0 (46…49) 0.999 0.881 (p < 0.001)**
Pain rating of TSinitial total 64.6 ± 6.8 (55…80) 64.6 ± 8.4 (45…80) 0.974 0.679 (p < 0.001)**
Mean of three pain rating of TSbefore total 60.5 ± 7.9 (50…82) 58.4 ± 5.8 (50…70) 0.376 0.411 (p < 0.05)
Pain rating of CS30s total 57.7 ± 17.9 (20…90) 56.7 ± 19.3 (20…88) 0.698 0.765 (p < 0.001)**
Mean of three pain rating of TSduring total 43.7 ± 10.0 (26…62) 38.9 ± 14.3 (10…65) 0.018 0.702 (p < 0.001)**
Pain rating of CS60s total 66.3 ± 20.1 (30…90) 67.5 ± 21.7 (30…95) 0.515 0.906 (p < 0.001)**
Mean of three pain rating of TSafter total 58.8 ± 11.7 (40…82) 50.8 ± 11.7 (23…70) 0.003* 0.480 (p < 0.01)
Pain rating of CS30s after total 57.9 ± 18.5 (15…85) 55.6 ± 19.3 (20…95) 0.282 0.843 (p < 0.001)**
Pain rating of CS60s after total 70.8 ± 19.2 (18…90) 69.5 ± 20.3 (20…95) 0.355 0.946 (p < 0.001)**
Early CPM effect total 16.7 ± 11.7 (−5…44) 19.5 ± 11.9 (−3…52) 0.187 0.618 (p < 0.001)**
Late CPM effect total 1.7 ± 9.2 (−25…18) 7.6 ± 11.5 (−5…37) 0.035 0.178 (p = 0.192)
  1. All values are presented as mean ± SD and range. All data represent pain ratings on the numeric rating scale (NRS, 0–100), unless otherwise indicated. CS conditioning stimulus, TS test stimulus; CPM conditioned pain modulation. The early CPM effect is calculated as the difference between mean pain ratings of TSbefore and TSduring. The late CPM effect is calculated as the difference between the mean pain ratings of TSbefore and TSafter
  2. apaired t-test CPM-effect day 1 vs. day 2
  3. bIntraclass Correlation Coefficient (ICC) between CPM parameters day 1 and day 2
  4. *p < 0.005 (after Bonferroni correction)
  5. ** p < 0.005 (after Bonferroni correction)