Table 2 Improvements in OHSA Item 1 scores from randomization to weeks 1, 2, and 4
Improvement, n (%) | NOH301 | NOH302 | NOH306 | Pooled | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Droxidopa (n = 82) | Placebo (n = 80) | P value* | Droxidopa (n = 50) | Placebo (n = 51) | P value* | Droxidopa (n = 92) | Placebo (n = 105) | P value* | Droxidopa (n = 174) | Placebo (n = 185) | P value* | |
Week 1 | ||||||||||||
≥ 2 units | 53 (64.6) | 33 (41.3) | 0.004 | – | – | – | 61 (66.3) | 46 (43.8) | 0.002 | 114 (65.5) | 79 (42.7) | <0.001 |
≥ 50 % | 45 (54.9) | 28 (35.0) | 0.017 | – | – | – | 51 (55.4) | 37 (35.2) | 0.006 | 96 (55.2) | 65 (35.1) | <0.001 |
Week 2 | ||||||||||||
≥ 2 units | – | – | – | 36 (72.0) | 29 (56.9) | NS | 49 (53.3) | 47 (44.8) | NS | 85 (59.9) | 76 (48.7) | NS |
≥ 50 % | – | – | – | 28 (56.0) | 23 (45.1) | NS | 38 (41.3) | 38 (36.2) | NS | 66 (46.5) | 61 (39.1) | NS |
Week 4 | ||||||||||||
≥ 2 units | – | – | – | – | – | – | 51 (55.4) | 46 (43.8) | NS | – | – | – |
≥ 50 % | – | – | – | – | – | – | 44 (47.8) | 32 (30.5) | 0.025 | – | – | – |
Week 8 | ||||||||||||
≥ 2 units | – | – | – | – | – | – | 51 (55.4) | 45 (42.9) | NS | – | – | – |
≥ 50 % | – | – | – | – | – | – | 47 (51.1) | 35 (33.3) | 0.023 | – | – | – |