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Table 6 Univariable and multivariable analyses of factors associated with cognitive disorders after acute ischemic stroke

From: Association between serum non-high-density lipoprotein cholesterol and cognitive impairment in patients with acute ischemic stroke

 

Univariable

Multivariable

Variables

P

OR

95 % CI

P

OR

95 % CI

Gender, male

0.239

0.729

0.431–1.234

   

Age

0.001

1.043

1.018–1.068

0.001

1.039

1.016–1.064

BMI

0.623

0.982

0.913–1.056

   

Years of education

<0.001

0.817

0.772–0.866

<0.001

0.808

0.757–0.861

Hypertension

0.324

1.207

0.831–1.755

   

Diabetes

<0.001

1.276

1.175–1.385

0.341

1.400

0.700–2.797

Coronary heart disease

0.388

1.380

0.664–2.870

   

History of smoking

0.367

1.226

0.788–1.907

   

History of drinking

0.524

1.221

0.661–2.254

   

Family history of dementia

0.001

1.219

1.082–1.374

0.055

0.242

0.057–1.031

History of stroke

0.021

1.742

1.087–2.791

0.025

1.723

1.071–2.771

High TC

0.629

0.791

0.306–2.044

   

High TG

0.674

1.078

0.760–1.529

   

Low HDL-C

0.088

0.650

0.396–1.066

   

High LDL-C

0.900

1.025

0.694–1.514

   

High Non-HDL-C

0.034

3.115

1.088–8.917

<0.001

3.115

1.088–8.917

Normal level

0.170

1.691

0.799–3.579

0.088

1.691

0.799–3.579

Higher than normal

0.046

2.710

1.017–7.221

0.052

2.710

1.017–7.221

Critical high level

0.026

5.877

1.231–28.065

0.040

5.877

1.231–28.065

Very high level

0.013

7.006

1.502–32.675

0.932

7.006

1.502–32.675

High Hcy

<0.001

1.060

1.032–1.088

<0.001

1.057

1.031–1.084

hsCRP

0.515

0.990

0.960–1.021

   

Fasting hyperglycemia [n (%)]

0.285

1.084

0.935–1.256

   

High HbA1c

0.960

1.002

0.939–1.068

   

NPI

0.218

1.039

0.978–1.104

   

HAMD-21

0.001

1.224

1.089–1.375

0.001

1.284

1.177–1.401

ADL

0.141

1.012

0.996–1.029

   
  1. BMI body mass index, Non-HDL-C non-high-density lipoprotein cholesterol, TC total cholesterol, TG triglycerides, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HCY homocysteine, hsCRP serum high-sensitivity C-reactive protein, HbA1c glycated hemoglobin, MMSE mini-mental state examination, MoCA Montreal Cognitive Assessment, NPI Neuropsychiatric Inventory, ADL Activity of Daily Living Scale, HADM-21 Hamilton depression rating scale 21-item