Fig. 1

Expression of adhesion molecules after 30 min MCAo/reperfusion. Experiments investigating mRNA expression (also Figs. 2 and 3 a, b, c) were performed in the same animals. Briefly, mRNA expression of VE-cadherin (a) and N-cadherin (b) was measured in ischemic brain tissue of wildtype and VE-cadherin heterozygous mice after 30 min MCAo/reperfusion or sham operation. 2 VEC^+/+ mice and 2 VEC^+/- animals assigned to the 72 h group died. Furthermore, 3 VEC^+/+ and 5 VEC^+/- mice assigned to the 28 d group died. The resultant group sizes were as follows: 3 VEC^+/+ sham, 3 VEC^+/- sham, 4 VEC^+/+ 6 h, 4 VEC^+/- 6 h, 4 VEC^+/+ 72 h, 4 VEC^+/- 72 h, 6 VEC^+/+ 28 d, 4 VEC^+/- 28 d. Relative mRNA expression is reported as the value normalized to tripeptidyl peptidase 2 (Tpp2) for each sample. One-way ANOVA, *p < 0.05 versus sham, #p < 0.05 between genotypes within time point